Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities

David P. Cormode; Willem J. M. Mulder; Zahi A. Fayad

doi:https://doi.org/10.1148/radiol.102011

Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities

David P. Cormode, Willem J. M. Mulder, Zahi A. Fayad

Medical Biochemistry (AMC)

Research output: Contribution to journal › Editorial › Academic › peer-review

7 Citations (Scopus)

Abstract

Pancreatic islet transplantation may provide an effective therapy for patients with type I diabetes. By encapsulating islets in alginate capsules, their survival is substantially improved. Methods to monitor the distribution of the encapsulated islets during delivery and afterward would help to optimize this type of therapy. Barnett and coworkers (1) showed, for the first time, it is possible to visualize encapsulated islets by using magnetic resonance (MR) imaging, computed tomography (CT), and ultrasonography (US) after the inclusion of perfluorocarbon in the capsules. Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice

Original language	English
Pages (from-to)	1-2
Journal	Radiology
Volume	258
Issue number	1
DOIs	https://doi.org/10.1148/radiol.102011
Publication status	Published - 2011

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https://doi.org/10.1148/radiol.102011

Cite this

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title = "Science to practice: versatile method to track transplanted encapsulated islet cells with multiple imaging modalities",

abstract = "Pancreatic islet transplantation may provide an effective therapy for patients with type I diabetes. By encapsulating islets in alginate capsules, their survival is substantially improved. Methods to monitor the distribution of the encapsulated islets during delivery and afterward would help to optimize this type of therapy. Barnett and coworkers (1) showed, for the first time, it is possible to visualize encapsulated islets by using magnetic resonance (MR) imaging, computed tomography (CT), and ultrasonography (US) after the inclusion of perfluorocarbon in the capsules. Importantly, it was shown that the therapeutic effect of the islets was sustained for more than 50 days when implanted into mice",

author = "Cormode, {David P.} and Mulder, {Willem J. M.} and Fayad, {Zahi A.}",

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