TY - JOUR
T1 - Semaphorin signaling
T2 - Molecular switches at the midline
AU - Derijck, Alwin A.H.A.
AU - Van Erp, Susan
AU - Pasterkamp, R. Jeroen
N1 - Funding Information: We thank Fanny Mann, Valérie Castellani and Yimin Zou for critical reading of the manuscript. Work in the authors’ laboratory on semaphorin signaling is supported by grants from the Netherlands Organization for Health Research and Development (ZonMW-VIDI/TOP), the Human Frontier Science Program (HFSP-CDA), and the ABC Genomics Center Utrecht (to R.J.P.).
PY - 2010/9
Y1 - 2010/9
N2 - To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents. How a navigating growth cone responds to a specific semaphorin is not absolute but instead depends on the biological context in which this cue is encountered. Here we review recent breakthroughs in our understanding of the extrinsic signals and molecular processes that control growth cone responses to class 3 semaphorins (Sema3s) at a well-characterized intermediate target, the spinal cord midline.
AB - To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents. How a navigating growth cone responds to a specific semaphorin is not absolute but instead depends on the biological context in which this cue is encountered. Here we review recent breakthroughs in our understanding of the extrinsic signals and molecular processes that control growth cone responses to class 3 semaphorins (Sema3s) at a well-characterized intermediate target, the spinal cord midline.
UR - http://www.scopus.com/inward/record.url?scp=77956191631&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.tcb.2010.06.007
DO - https://doi.org/10.1016/j.tcb.2010.06.007
M3 - Review article
C2 - 20655749
SN - 0962-8924
VL - 20
SP - 568
EP - 576
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 9
ER -