TY - JOUR
T1 - Sensitivity analysis of Raman endoscopy with and without wavefront shaping
AU - Amitonova, Lyubov V.
AU - de Boer, Johannes F.
PY - 2020/2/3
Y1 - 2020/2/3
N2 - Vibrational spectroscopy is a powerful method for the label-free identification of molecules. Spontaneous Raman spectroscopy integrated with an ultra-thin fiber-based endoscope can provide remote, local, and minimally invasive chemical analysis in many fields from biomedical diagnostics to the materials industry. Miniaturization of the probe in combination with a large field of view (FOV) and high sensitivity would be beneficial for a broad class of applications. Here we quantitatively analyze signal-to-noise ratio (SNR) and the sensitivity improvement due to wavefront shaping. We show that wavefront shaping in an ultra-thin single-fiber probe allows to decrease the total measurements time up to several orders of magnitude even without any prior knowledge of the Raman particle location. Such a fiber probe is well suited for minimally-invasive endoscopy in biological and medical applications.
AB - Vibrational spectroscopy is a powerful method for the label-free identification of molecules. Spontaneous Raman spectroscopy integrated with an ultra-thin fiber-based endoscope can provide remote, local, and minimally invasive chemical analysis in many fields from biomedical diagnostics to the materials industry. Miniaturization of the probe in combination with a large field of view (FOV) and high sensitivity would be beneficial for a broad class of applications. Here we quantitatively analyze signal-to-noise ratio (SNR) and the sensitivity improvement due to wavefront shaping. We show that wavefront shaping in an ultra-thin single-fiber probe allows to decrease the total measurements time up to several orders of magnitude even without any prior knowledge of the Raman particle location. Such a fiber probe is well suited for minimally-invasive endoscopy in biological and medical applications.
UR - http://www.scopus.com/inward/record.url?scp=85078857210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078857210&partnerID=8YFLogxK
U2 - https://doi.org/10.1364/OE.383801
DO - https://doi.org/10.1364/OE.383801
M3 - Article
C2 - 32122039
SN - 1094-4087
VL - 28
SP - 3779
EP - 3788
JO - Optics express
JF - Optics express
IS - 3
ER -