Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis

M.H.G.M. van der Pas; S. Meijer; O.S. Hoekstra; I. Riphagen; H.C.W. de Vet; D.L. Knol; N.C.T. van Grieken; W.J.H.J. Meijerink

doi:https://doi.org/10.1016/S1470-2045(11)70075-4

Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis

M.H.G.M. van der Pas, S. Meijer, O.S. Hoekstra, I. Riphagen, H.C.W. de Vet, D.L. Knol, N.C.T. van Grieken, W.J.H.J. Meijerink

Research output: Contribution to journal › Article › Academic › peer-review

118 Citations (Scopus)

Abstract

Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ

Original language	English
Pages (from-to)	540-550
Journal	lancet oncology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S1470-2045(11)70075-4
Publication status	Published - 2011

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https://doi.org/10.1016/S1470-2045(11)70075-4

Cite this

@article{24258896becb4907b66545926a4f04bf,

title = "Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis",

abstract = "Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ",

author = "{van der Pas}, M.H.G.M. and S. Meijer and O.S. Hoekstra and I. Riphagen and {de Vet}, H.C.W. and D.L. Knol and {van Grieken}, N.C.T. and W.J.H.J. Meijerink",

year = "2011",

doi = "https://doi.org/10.1016/S1470-2045(11)70075-4",

language = "English",

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journal = "lancet oncology",

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T1 - Sentinel-lymph-node procedure in colon and rectal cancer: a systematic review and meta-analysis

AU - van der Pas, M.H.G.M.

AU - Meijer, S.

AU - Hoekstra, O.S.

AU - Riphagen, I.

AU - de Vet, H.C.W.

AU - Knol, D.L.

AU - van Grieken, N.C.T.

AU - Meijerink, W.J.H.J.

PY - 2011

Y1 - 2011

N2 - Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ

AB - Background: No consensus exists on the validity of the sentinel-lymph-node procedure for assessment of nodal status in patients with colorectal cancer. We aimed to assess the diagnostic performance of this procedure. Methods: We searched Embase and PubMed databases for studies published before March 20, 2010. Eligible studies had a prospective design, a sample size of at least 20 patients, and reported the rate of sentinel-lymph-node positivity. Individual patient data were requested for localisation and T-stage stratification. A subset of reports with high methodological quality was selected and analysed. Findings: We identified 52 eligible studies, which included 3767 sentinel-lymph-node procedures (2961 [78·6%] colon and 806 [21·4%] rectal carcinomas). Most tumours 2339 (62·1%) were stage T3 or T4. 1887 (50·1%) of patients were male, 1880 (49·9%) female. Mean overall weighted-detection rate was 0·94 (95% CI 0·92-0·95), at a pooled sensitivity of 0·76 (0·72-0·80) with limited heterogeneity (χ

U2 - https://doi.org/10.1016/S1470-2045(11)70075-4

DO - https://doi.org/10.1016/S1470-2045(11)70075-4

M3 - Article

SN - 1470-2045

VL - 12

SP - 540

EP - 550

JO - lancet oncology

JF - lancet oncology

IS - 6

ER -