TY - JOUR
T1 - Sepsis: a roadmap for future research
AU - Cohen, Jonathan
AU - Vincent, Jean-Louis
AU - Adhikari, Neill K. J.
AU - Machado, Flavia R.
AU - Angus, Derek C.
AU - Calandra, Thierry
AU - Jaton, Katia
AU - Giulieri, Stefano
AU - Delaloye, Julie
AU - Opal, Steven
AU - Tracey, Kevin
AU - van der Poll, Tom
AU - Pelfrene, Eric
PY - 2015
Y1 - 2015
N2 - Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research
AB - Sepsis is a common and lethal syndrome: although outcomes have improved, mortality remains high. No specific anti-sepsis treatments exist; as such, management of patients relies mainly on early recognition allowing correct therapeutic measures to be started rapidly, including administration of appropriate antibiotics, source control measures when necessary, and resuscitation with intravenous fluids and vasoactive drugs when needed. Although substantial developments have been made in the understanding of the basic pathogenesis of sepsis and the complex interplay of host, pathogen, and environment that affect the incidence and course of the disease, sepsis has stubbornly resisted all efforts to successfully develop and then deploy new and improved treatments. Existing models of clinical research seem increasingly unlikely to produce new therapies that will result in a step change in clinical outcomes. In this Commission, we set out our understanding of the clinical epidemiology and management of sepsis and then ask how the present approaches might be challenged to develop a new roadmap for future research
U2 - https://doi.org/10.1016/S1473-3099(15)70112-X
DO - https://doi.org/10.1016/S1473-3099(15)70112-X
M3 - Article
C2 - 25932591
SN - 1473-3099
VL - 15
SP - 581
EP - 614
JO - Lancet infectious diseases
JF - Lancet infectious diseases
IS - 5
ER -