Sequential comparison of therapy with beta-blockers and calcium channel blockers with celiprolol therapy in patients with angina pectoris, hypertension, or both

Unlike patients with either hypertension (HT) of angina pectoris (AP) alone, patients with both HT and AP usually have a reduced left ventricular compliance and may, therefore, have an impaired capability to cope with acute hemodynamic changes generated by standard beta-blockers or calcium channel blockers, Celiprolol has been documented to produce fewer adverse effects and equal efficacy compared with standard beta-blockers or calcium channel blockers. We carried out a 16-week open-lab, sequential comparison of standard monotherapy versus celiprolol in 172 patients,vith either HT alone, AP alone, or HT + AP. We compared the effects on symptoms and adverse effects, The recurrence of adverse effects from drug therapy was definitely more common in the HT + AP patients than in patients with AP alone or HT alone. Despite this imbalance In the groups, celiprolol overall produced fewer occurrences of fatigue, dizziness, and edema. Celiprolol controlled AP and HT to the same extent as did standard monotherapy, Our data, although preliminary, suggest that patients with both HT and AP are prone to adverse effects of standard drug therapy, and that celiprolol, while equally effective, is largely devoid of adverse effects as compared with standard therapy, particularly in patients with both HT aid AP