TY - JOUR
T1 - Serial 5-year evaluation of side branches jailed by bioresorbable vascular scaffolds using 3-dimensional optical coherence tomography insights from the ABSORB cohort b trial (a clinical evaluation of the bioabsorbable everolimus eluting coronary stent system in the treatment of patients with de novo native coronary artery lesions)
AU - Onuma, Yoshinobu
AU - Grundeken, Maik J.
AU - Nakatani, Shimpei
AU - Asano, Taku
AU - Sotomi, Yohei
AU - Foin, Nicolas
AU - Ng, Jaryl
AU - Okamura, Takayuki
AU - Wykrzykowska, Joanna J.
AU - de Winter, Robbert J.
AU - van Geuns, Robert-Jan
AU - Koolen, Jacques
AU - Christiansen, Evald
AU - Whitbourn, Robert
AU - McClean, Dougal
AU - Smits, Pieter
AU - Windecker, Stephan
AU - Ormiston, John A.
AU - Serruys, Patrick W.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background-The long-term fate of Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, CA) struts jailing side branch ostia has not been clarified. We therefore evaluate serially (post-procedure and at 6 months, 1, 2, 3, and 5 years) the appearance and fate of jailed Absorb bioresorbable vascular scaffold struts. Methods and Results-We performed 3-dimensional optical coherence tomographic analysis of the ABSORB Cohort B trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) up to 5 years using a novel, validated cut-plane analysis method. We included 29 patients with a total of 85 side branch ostia. From the 12 ostia which could be assessed in true serial fashion, 7 showed a pattern of initial decrease in the ostial area free from struts, followed by an increase in strut-free ostial area toward the end of the 5 years of follow-up. In a repeated-measures analysis with time as fixed variable and ostial area free from struts as dependent variable, we showed a numeric decrease in the estimated ostial area free from struts from 0.75 mm2 (baseline) to 0.68 mm2 (first follow-up visit at 6 months or 1 year) and 0.63 mm2 (second follow-up visit at 2 or 3 years). However, from the second visit to the 5-year follow-up visit, there was a statistically significant increase from 0.63 to 0.89 mm2 (P=0.001). Struts overlying an ostium divided the ostium into compartments, and the number of these compartments decreased over time. Conclusions-This study showed that in most cases, the side branch ostial area free from struts initially decreased. However, with full scaffold bioresorption, the ostial area free from scaffold increased between 2 to 3 years and 5 years in the vast majority of patients..
AB - Background-The long-term fate of Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, CA) struts jailing side branch ostia has not been clarified. We therefore evaluate serially (post-procedure and at 6 months, 1, 2, 3, and 5 years) the appearance and fate of jailed Absorb bioresorbable vascular scaffold struts. Methods and Results-We performed 3-dimensional optical coherence tomographic analysis of the ABSORB Cohort B trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) up to 5 years using a novel, validated cut-plane analysis method. We included 29 patients with a total of 85 side branch ostia. From the 12 ostia which could be assessed in true serial fashion, 7 showed a pattern of initial decrease in the ostial area free from struts, followed by an increase in strut-free ostial area toward the end of the 5 years of follow-up. In a repeated-measures analysis with time as fixed variable and ostial area free from struts as dependent variable, we showed a numeric decrease in the estimated ostial area free from struts from 0.75 mm2 (baseline) to 0.68 mm2 (first follow-up visit at 6 months or 1 year) and 0.63 mm2 (second follow-up visit at 2 or 3 years). However, from the second visit to the 5-year follow-up visit, there was a statistically significant increase from 0.63 to 0.89 mm2 (P=0.001). Struts overlying an ostium divided the ostium into compartments, and the number of these compartments decreased over time. Conclusions-This study showed that in most cases, the side branch ostial area free from struts initially decreased. However, with full scaffold bioresorption, the ostial area free from scaffold increased between 2 to 3 years and 5 years in the vast majority of patients..
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029748243&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28893770
U2 - https://doi.org/10.1161/CIRCINTERVENTIONS.116.004393
DO - https://doi.org/10.1161/CIRCINTERVENTIONS.116.004393
M3 - Article
C2 - 28893770
SN - 1941-7640
VL - 10
JO - Circulation. Cardiovascular interventions
JF - Circulation. Cardiovascular interventions
IS - 9
M1 - e004393
ER -