TY - JOUR
T1 - Serine proteases of the human immune system in health and disease
AU - Heutinck, Kirstin M.
AU - ten Berge, Ineke J. M.
AU - Hack, C. Erik
AU - Hamann, Jörg
AU - Rowshani, Ajda T.
PY - 2010
Y1 - 2010
N2 - Serine proteases form a large family of protein-cleaving enzymes that play an essential role in processes like blood coagulation, apoptosis and inflammation. Immune cells express a wide variety of serine proteases such as granzymes in cytotoxic lymphocytes, neutrophil elastase, cathepsin G and proteinase 3 in neutrophils and chymase and tryptase in mast cells. Regulation of proteolysis induced by these serine proteases is essential to prevent self-induced damage Hence, there are specialized serine protease inhibitors, serpins, which are broadly distributed Here, we discuss the function of human serine proteases in inflammation, apoptosis and tissue remodeling. Furthermore, we address their Impact on development and progression of immune mediated-diseases Understanding the mode of action of senile proteases will help to unravel molecular processes involved in immunological disorders and will facilitate the identification of new therapeutic targets. (C) 2010 Elsevier Ltd All rights reserved
AB - Serine proteases form a large family of protein-cleaving enzymes that play an essential role in processes like blood coagulation, apoptosis and inflammation. Immune cells express a wide variety of serine proteases such as granzymes in cytotoxic lymphocytes, neutrophil elastase, cathepsin G and proteinase 3 in neutrophils and chymase and tryptase in mast cells. Regulation of proteolysis induced by these serine proteases is essential to prevent self-induced damage Hence, there are specialized serine protease inhibitors, serpins, which are broadly distributed Here, we discuss the function of human serine proteases in inflammation, apoptosis and tissue remodeling. Furthermore, we address their Impact on development and progression of immune mediated-diseases Understanding the mode of action of senile proteases will help to unravel molecular processes involved in immunological disorders and will facilitate the identification of new therapeutic targets. (C) 2010 Elsevier Ltd All rights reserved
U2 - https://doi.org/10.1016/j.molimm.2010.04.020
DO - https://doi.org/10.1016/j.molimm.2010.04.020
M3 - Review article
C2 - 20537709
SN - 0161-5890
VL - 47
SP - 1943
EP - 1955
JO - Molecular immunology
JF - Molecular immunology
IS - 11-12
ER -