Seroconversion to HCoV-NL63 in Rhesus Macaques

Ronald Dijkman; H. Lie Mulder; Lynne Rumping; Ilse Kraaijvanger; Martin Deijs; Maarten F. Jebbink; Ernst J. Verschoor; Lia van der Hoek

doi:https://doi.org/10.3390/v1030647

Seroconversion to HCoV-NL63 in Rhesus Macaques

Ronald Dijkman, H. Lie Mulder, Lynne Rumping, Ilse Kraaijvanger, Martin Deijs, Maarten F. Jebbink, Ernst J. Verschoor, Lia van der Hoek

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63

Original language	English
Pages (from-to)	647-656
Journal	Viruses
Volume	1
Issue number	3
DOIs	https://doi.org/10.3390/v1030647
Publication status	Published - 2009

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https://doi.org/10.3390/v1030647

Cite this

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abstract = "HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63",

author = "Ronald Dijkman and Mulder, {H. Lie} and Lynne Rumping and Ilse Kraaijvanger and Martin Deijs and Jebbink, {Maarten F.} and Verschoor, {Ernst J.} and {van der Hoek}, Lia",

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AU - Dijkman, Ronald

AU - Mulder, H. Lie

AU - Rumping, Lynne

AU - Kraaijvanger, Ilse

AU - Deijs, Martin

AU - Jebbink, Maarten F.

AU - Verschoor, Ernst J.

AU - van der Hoek, Lia

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AB - HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63

U2 - https://doi.org/10.3390/v1030647

DO - https://doi.org/10.3390/v1030647

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