Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

B. M. de Jong; M. G. Feenstra; J. M. Ruijter; E. A. van Royen

doi:https://doi.org/10.1016/0014-4886(89)90055-1

Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

B. M. de Jong, M. G. Feenstra, J. M. Ruijter, E. A. van Royen

Other Departments

Research output: Contribution to journal › Comment/Letter to the editor › Academic

2 Citations (Scopus)

Abstract

In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

Original language	English
Pages (from-to)	297-299
Journal	Experimental neurology
Volume	103
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(89)90055-1
Publication status	Published - 1989

Access to Document

https://doi.org/10.1016/0014-4886(89)90055-1

Cite this

@article{f6a113339a7d4fe5b4125d026b54b2ae,

title = "Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine",

abstract = "In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system",

author = "{de Jong}, {B. M.} and Feenstra, {M. G.} and Ruijter, {J. M.} and {van Royen}, {E. A.}",

year = "1989",

doi = "https://doi.org/10.1016/0014-4886(89)90055-1",

language = "English",

volume = "103",

pages = "297--299",

journal = "Experimental neurology",

issn = "0014-4886",

publisher = "Academic Press Inc.",

number = "3",

}

TY - JOUR

T1 - Serotonin uptake in cerebral cortex cultures: imipramine-like inhibition by N-isopropyl-p-iodoamphetamine

AU - de Jong, B. M.

AU - Feenstra, M. G.

AU - Ruijter, J. M.

AU - van Royen, E. A.

PY - 1989

Y1 - 1989

N2 - In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

AB - In cultured rat neocortex, uptake of [3H]serotonin (5-HT) and the SPECT radiopharmaceutical N-isopropyl-p-[123I]iodoamphetamine (IMP) was demonstrated after 4 and 14 days in vitro. Both imipramine and cold IMP inhibited [3H]5-HT uptake. Uptake of [123I]IMP was inhibited by imipramine but not by cold 5-HT. The similarity in the behaviors of IMP and imipramine indicates that uptake of IMP might be related to a serotonergic uptake system in a way that is similar to that in which imipramine is related to such a system

U2 - https://doi.org/10.1016/0014-4886(89)90055-1

DO - https://doi.org/10.1016/0014-4886(89)90055-1

M3 - Comment/Letter to the editor

C2 - 2920796

SN - 0014-4886

VL - 103

SP - 297

EP - 299

JO - Experimental neurology

JF - Experimental neurology

IS - 3

ER -