Serrated lesions of the colon and rectum: the role of advanced endoscopic imaging

J L A Vleugels; J E G IJspeert; E Dekker

doi:https://doi.org/10.1016/j.bpg.2015.05.009

Serrated lesions of the colon and rectum: the role of advanced endoscopic imaging

J L A Vleugels, J E G IJspeert, E Dekker

Gastroenterology and Hepatology (VUmc)

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Conventional adenomas were traditionally thought to be the only precursors to colorectal cancer (CRC). Nowadays, also serrated polyps are acknowledged as precursor lesions for CRC, responsible for up to 30% of all CRCs and probably a larger percentage of interval CRCs after colonoscopy. In recent years, much research is being done to unravel the serrated neoplasia pathway. Endoscopic detection of serrated polyps is still a challenge for gastroenterologists, which is illustrated by large variations in detection rates of serrated polyps in the proximal colon. Clinical practice is further inhibited by poor optical differentiation of SSA/Ps from conventional adenomas and HPs and difficult delineation of those lesions, resulting in incomplete resection. The main focus of this review is to highlight recent advancements in endoscopic imaging techniques with regards to detection, differentiation and resection of serrated polyps.

Original language	English
Pages (from-to)	675-86
Number of pages	12
Journal	Baillière's Best Practice and Research. Clinical Gastroenterology
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.bpg.2015.05.009
Publication status	Published - Aug 2015

Keywords

Colonic Polyps/diagnosis
Colonoscopy
Colorectal Neoplasms/diagnosis
Diagnosis, Differential
Diagnostic Imaging
Humans
Precancerous Conditions/diagnosis

Access to Document

https://doi.org/10.1016/j.bpg.2015.05.009

Cite this

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title = "Serrated lesions of the colon and rectum: the role of advanced endoscopic imaging",

abstract = "Conventional adenomas were traditionally thought to be the only precursors to colorectal cancer (CRC). Nowadays, also serrated polyps are acknowledged as precursor lesions for CRC, responsible for up to 30% of all CRCs and probably a larger percentage of interval CRCs after colonoscopy. In recent years, much research is being done to unravel the serrated neoplasia pathway. Endoscopic detection of serrated polyps is still a challenge for gastroenterologists, which is illustrated by large variations in detection rates of serrated polyps in the proximal colon. Clinical practice is further inhibited by poor optical differentiation of SSA/Ps from conventional adenomas and HPs and difficult delineation of those lesions, resulting in incomplete resection. The main focus of this review is to highlight recent advancements in endoscopic imaging techniques with regards to detection, differentiation and resection of serrated polyps.",

keywords = "Colonic Polyps/diagnosis, Colonoscopy, Colorectal Neoplasms/diagnosis, Diagnosis, Differential, Diagnostic Imaging, Humans, Precancerous Conditions/diagnosis",

author = "Vleugels, {J L A} and IJspeert, {J E G} and E Dekker",

year = "2015",

month = aug,

doi = "https://doi.org/10.1016/j.bpg.2015.05.009",

language = "English",

volume = "29",

pages = "675--86",

journal = "Bailli{\`e}re's Best Practice and Research. Clinical Gastroenterology",

issn = "1521-6918",

publisher = "Bailliere Tindall Ltd",

number = "4",

}

TY - JOUR

T1 - Serrated lesions of the colon and rectum

T2 - the role of advanced endoscopic imaging

AU - Vleugels, J L A

AU - IJspeert, J E G

AU - Dekker, E

PY - 2015/8

Y1 - 2015/8

N2 - Conventional adenomas were traditionally thought to be the only precursors to colorectal cancer (CRC). Nowadays, also serrated polyps are acknowledged as precursor lesions for CRC, responsible for up to 30% of all CRCs and probably a larger percentage of interval CRCs after colonoscopy. In recent years, much research is being done to unravel the serrated neoplasia pathway. Endoscopic detection of serrated polyps is still a challenge for gastroenterologists, which is illustrated by large variations in detection rates of serrated polyps in the proximal colon. Clinical practice is further inhibited by poor optical differentiation of SSA/Ps from conventional adenomas and HPs and difficult delineation of those lesions, resulting in incomplete resection. The main focus of this review is to highlight recent advancements in endoscopic imaging techniques with regards to detection, differentiation and resection of serrated polyps.

AB - Conventional adenomas were traditionally thought to be the only precursors to colorectal cancer (CRC). Nowadays, also serrated polyps are acknowledged as precursor lesions for CRC, responsible for up to 30% of all CRCs and probably a larger percentage of interval CRCs after colonoscopy. In recent years, much research is being done to unravel the serrated neoplasia pathway. Endoscopic detection of serrated polyps is still a challenge for gastroenterologists, which is illustrated by large variations in detection rates of serrated polyps in the proximal colon. Clinical practice is further inhibited by poor optical differentiation of SSA/Ps from conventional adenomas and HPs and difficult delineation of those lesions, resulting in incomplete resection. The main focus of this review is to highlight recent advancements in endoscopic imaging techniques with regards to detection, differentiation and resection of serrated polyps.

KW - Colonic Polyps/diagnosis

KW - Colonoscopy

KW - Colorectal Neoplasms/diagnosis

KW - Diagnosis, Differential

KW - Diagnostic Imaging

KW - Humans

KW - Precancerous Conditions/diagnosis

U2 - https://doi.org/10.1016/j.bpg.2015.05.009

DO - https://doi.org/10.1016/j.bpg.2015.05.009

M3 - Review article

C2 - 26381311

SN - 1521-6918

VL - 29

SP - 675

EP - 686

JO - Baillière's Best Practice and Research. Clinical Gastroenterology

JF - Baillière's Best Practice and Research. Clinical Gastroenterology

IS - 4

ER -