TY - JOUR
T1 - Serum 25-hydroxyvitamin D in relation to disability in activities of daily living, mobility, and objective physical functioning among Chinese older adults
AU - Cao, Xingqi
AU - Ying, Zhimin
AU - Li, Xueqin
AU - Zhang, Jingyun
AU - Hoogendijk, Emiel O
AU - Liu, Zuyun
N1 - Funding Information: The data used in this study were from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which is managed by the Center for Healthy Aging and Development Studies, Peking University. The CLHLS was supported by funds from the U.S. National Institutes on Aging (grant number R01AG023627), China National Natural Science Foundation (grant numbers 71233001, 71110107025), China Social Science Foundation, and UNFPA. This work was supported by the funds from the Zhejiang Medical and Health Science and Technology Project (grant number 2018273938 , 2020386961 ). The current study was conducted at the School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine. The funders had no role in the study design; data collection, analysis, or interpretation; in the writing of the report; or in the decision to submit the article for publication. Funding Information: The data used in this study were from the Chinese Longitudinal Healthy Longevity Survey (CLHLS), which is managed by the Center for Healthy Aging and Development Studies, Peking University. The CLHLS was supported by funds from the U.S. National Institutes on Aging (grant number R01AG023627), China National Natural Science Foundation (grant numbers 71233001, 71110107025), China Social Science Foundation, and UNFPA. This work was supported by the funds from the Zhejiang Medical and Health Science and Technology Project (grant number 2018273938, 2020386961). The current study was conducted at the School of Public Health and the Second Affiliated Hospital, Zhejiang University School of Medicine. The funders had no role in the study design; data collection, analysis, or interpretation; in the writing of the report; or in the decision to submit the article for publication. Publisher Copyright: © 2021 Elsevier Inc. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - OBJECTIVES: Vitamin D deficiency is common among older adults, but its association with physical function is not fully understood. The aim of this study was to investigate the associations between serum 25-hydroxyvitamin D and disability in activities of daily living (ADL), mobility, and objective physical functioning among Chinese older adults.METHODS: We used cross-sectional data of 2225 older adults (≥65 years) who participated in the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Serum levels of 25-hydroxyvitamin D were measured by enzyme immunoassay. Outcomes included ADL disability, mobility disability, and disability in three objective physical examinations (standing-up from a chair, picking-up a book from the floor, and turning-around 360°).RESULTS: The multiple regression models suggested that participants in the serum 25-hydroxyvitamin D deficiency group had higher odds of ADL disability (OR: 4.08; 95% confidence interval (CI): 2.81, 5.92), mobility disability (OR: 1.59; 95% CI: 1.05, 2.41), and disability in standing-up from a chair (OR: 2.43; 95% CI: 1.60, 3.69), picking-up a book from the floor (OR: 3.09; 95% CI: 2.07, 4.60), and turning-around 360° (OR: 3.09; 95% CI: 2.07, 4.60). Subgroup analyses revealed that some of the above associations (particularly those with mobility disability and disability in turning-around 360°) were only statistically significant among the oldest-old.CONCLUSIONS: Among the oldest-old in China, serum 25-hydroxyvitamin D deficiency was associated with disability in ADL, mobility, and objective physical functioning, highlighting the importance of managing the serum 25-hydroxyvitamin D level to promote healthy aging.
AB - OBJECTIVES: Vitamin D deficiency is common among older adults, but its association with physical function is not fully understood. The aim of this study was to investigate the associations between serum 25-hydroxyvitamin D and disability in activities of daily living (ADL), mobility, and objective physical functioning among Chinese older adults.METHODS: We used cross-sectional data of 2225 older adults (≥65 years) who participated in the 2011/2012 main survey of the Chinese Longitudinal Healthy Longevity Survey (CLHLS) and the 2012 biomarker sub-study. Serum levels of 25-hydroxyvitamin D were measured by enzyme immunoassay. Outcomes included ADL disability, mobility disability, and disability in three objective physical examinations (standing-up from a chair, picking-up a book from the floor, and turning-around 360°).RESULTS: The multiple regression models suggested that participants in the serum 25-hydroxyvitamin D deficiency group had higher odds of ADL disability (OR: 4.08; 95% confidence interval (CI): 2.81, 5.92), mobility disability (OR: 1.59; 95% CI: 1.05, 2.41), and disability in standing-up from a chair (OR: 2.43; 95% CI: 1.60, 3.69), picking-up a book from the floor (OR: 3.09; 95% CI: 2.07, 4.60), and turning-around 360° (OR: 3.09; 95% CI: 2.07, 4.60). Subgroup analyses revealed that some of the above associations (particularly those with mobility disability and disability in turning-around 360°) were only statistically significant among the oldest-old.CONCLUSIONS: Among the oldest-old in China, serum 25-hydroxyvitamin D deficiency was associated with disability in ADL, mobility, and objective physical functioning, highlighting the importance of managing the serum 25-hydroxyvitamin D level to promote healthy aging.
KW - 25-Hydroxyvitamin D
KW - Activities of daily living
KW - Mobility limitation
KW - Physical functional performance
KW - The oldest-old
UR - http://www.scopus.com/inward/record.url?scp=85101928282&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.exger.2021.111290
DO - https://doi.org/10.1016/j.exger.2021.111290
M3 - Article
C2 - 33647362
SN - 0531-5565
VL - 148
SP - 111290
JO - Experimental gerontology
JF - Experimental gerontology
M1 - 111290
ER -