TY - JOUR
T1 - Serum albumin and muscle measures in a cohort of healthy young and old participants
AU - Reijnierse, E.M.
AU - Trappenburg, M.C.
AU - Leter, M.J.
AU - Sipila, S.
AU - Stenroth, L.
AU - Narici, M.V.
AU - Hogrel, J.Y.
AU - Butler-Browne, G.
AU - McPhee, J.S.
AU - Paasuke, M.
AU - Gapeyeva, H.
AU - Meskers, C.G.M.
AU - Maier, A.B.
AU - Sipilä, S
AU - Pääsuke, M
PY - 2015/10
Y1 - 2015/10
N2 - Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.
AB - Consensus on clinically valid diagnostic criteria for sarcopenia requires a systematical assessment of the association of its candidate measures of muscle mass, muscle strength, and physical performance on one side and muscle-related clinical parameters on the other side. In this study, we systematically assessed associations between serum albumin as a muscle-related parameter and muscle measures in 172 healthy young (aged 18-30 years) and 271 old participants (aged 69-81 year) from the European MYOAGE study. Muscle measures included relative muscle mass, i.e., total- and appendicular lean mass (ALM) percentage, absolute muscle mass, i.e., ALM/height(2) and total lean mass in kilograms, handgrip strength, and walking speed. Muscle measures were standardized and analyzed in multivariate linear regression models, stratified by age. Adjustment models included age, body composition, C-reactive protein and lifestyle factors. In young participants, serum albumin was positively associated with lean mass percentage (p = 0.007) and with ALM percentage (p = 0.001). In old participants, serum albumin was not associated with any of the muscle measures. In conclusion, the association between serum albumin and muscle measures was only found in healthy young participants and the strongest for measures of relative muscle mass.
KW - Absorptiometry, Photon
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Aging/physiology
KW - Body Composition/physiology
KW - C-Reactive Protein/metabolism
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Life Style
KW - Male
KW - Muscle Strength/physiology
KW - Reference Values
KW - Sarcopenia/metabolism
KW - Serum Albumin/metabolism
KW - Young Adult
U2 - https://doi.org/10.1007/s11357-015-9825-6
DO - https://doi.org/10.1007/s11357-015-9825-6
M3 - Article
C2 - 26310888
SN - 0161-9152
VL - 37
JO - Age
JF - Age
IS - 5
M1 - 88
ER -