SERUM IGD LEVELS IN MICE - EFFECT OF STRAIN, AGE AND AUTOIMMUNE-DISEASE

R. F. van Vollenhoven; C. D. Swenson; A. Soriano; E. A. Goidl; R. F. Coico; G. J. Thorbecke; G. W. Siskind

doi:https://doi.org/10.1016/0896-8411(89)90268-0

SERUM IGD LEVELS IN MICE - EFFECT OF STRAIN, AGE AND AUTOIMMUNE-DISEASE

R. F. van Vollenhoven, C. D. Swenson, A. Soriano, E. A. Goidl, R. F. Coico, G. J. Thorbecke, G. W. Siskind

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Abstract

Serum IgD levels were studied in mice. Strain-related variability of serum IgD levels was noted, and advanced age was associated with markedly increased IgD levels in a large percentage of mice from all strains. Strains prone to spontaneously arising autoimmune disease had elevated IgD levels; in NZB mice this was already present very early after birth (one week), whereas in MRL mice the elevated serum IgD levels were first seen somewhat later (3 months). In contrast, mice with collagen type II (CII)-induced autoimmune arthritis had no increase in serum IgD. Injection of the immunomodulating agents LPS and complete Freund's adjuvant (CFA) did not have a significant effect on serum IgD levels, but IL-1 induced a significant decrease in IgD

Original language	English
Pages (from-to)	259-267
Journal	Journal of autoimmunity
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/0896-8411(89)90268-0
Publication status	Published - 1989
Externally published	Yes

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https://doi.org/10.1016/0896-8411(89)90268-0

Cite this

@article{fe18d1974c7c48f09c25dcda58368c1d,

title = "SERUM IGD LEVELS IN MICE - EFFECT OF STRAIN, AGE AND AUTOIMMUNE-DISEASE",

abstract = "Serum IgD levels were studied in mice. Strain-related variability of serum IgD levels was noted, and advanced age was associated with markedly increased IgD levels in a large percentage of mice from all strains. Strains prone to spontaneously arising autoimmune disease had elevated IgD levels; in NZB mice this was already present very early after birth (one week), whereas in MRL mice the elevated serum IgD levels were first seen somewhat later (3 months). In contrast, mice with collagen type II (CII)-induced autoimmune arthritis had no increase in serum IgD. Injection of the immunomodulating agents LPS and complete Freund's adjuvant (CFA) did not have a significant effect on serum IgD levels, but IL-1 induced a significant decrease in IgD",

author = "{van Vollenhoven}, {R. F.} and Swenson, {C. D.} and A. Soriano and Goidl, {E. A.} and Coico, {R. F.} and Thorbecke, {G. J.} and Siskind, {G. W.}",

year = "1989",

doi = "https://doi.org/10.1016/0896-8411(89)90268-0",

language = "English",

volume = "2",

pages = "259--267",

journal = "Journal of autoimmunity",

issn = "0896-8411",

publisher = "Academic Press Inc.",

number = "3",

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TY - JOUR

T1 - SERUM IGD LEVELS IN MICE - EFFECT OF STRAIN, AGE AND AUTOIMMUNE-DISEASE

AU - van Vollenhoven, R. F.

AU - Swenson, C. D.

AU - Soriano, A.

AU - Goidl, E. A.

AU - Coico, R. F.

AU - Thorbecke, G. J.

AU - Siskind, G. W.

PY - 1989

Y1 - 1989

N2 - Serum IgD levels were studied in mice. Strain-related variability of serum IgD levels was noted, and advanced age was associated with markedly increased IgD levels in a large percentage of mice from all strains. Strains prone to spontaneously arising autoimmune disease had elevated IgD levels; in NZB mice this was already present very early after birth (one week), whereas in MRL mice the elevated serum IgD levels were first seen somewhat later (3 months). In contrast, mice with collagen type II (CII)-induced autoimmune arthritis had no increase in serum IgD. Injection of the immunomodulating agents LPS and complete Freund's adjuvant (CFA) did not have a significant effect on serum IgD levels, but IL-1 induced a significant decrease in IgD

AB - Serum IgD levels were studied in mice. Strain-related variability of serum IgD levels was noted, and advanced age was associated with markedly increased IgD levels in a large percentage of mice from all strains. Strains prone to spontaneously arising autoimmune disease had elevated IgD levels; in NZB mice this was already present very early after birth (one week), whereas in MRL mice the elevated serum IgD levels were first seen somewhat later (3 months). In contrast, mice with collagen type II (CII)-induced autoimmune arthritis had no increase in serum IgD. Injection of the immunomodulating agents LPS and complete Freund's adjuvant (CFA) did not have a significant effect on serum IgD levels, but IL-1 induced a significant decrease in IgD

U2 - https://doi.org/10.1016/0896-8411(89)90268-0

DO - https://doi.org/10.1016/0896-8411(89)90268-0

M3 - Article

C2 - 2765098

SN - 0896-8411

VL - 2

SP - 259

EP - 267

JO - Journal of autoimmunity

JF - Journal of autoimmunity

IS - 3

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