TY - JOUR
T1 - Severe fetal hemolysis and cholestasis due to high-titer maternal IgG anti-A antibodies
AU - Zonneveld, Rens
AU - van der Meer-Kapelle, Laura
AU - Sylva, Marc
AU - Brand, Anneke
AU - Zijlstra, Marianne
AU - Schonewille, Henk
PY - 2019
Y1 - 2019
N2 - ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O/A HDFN associated with extremely high-titer (1:32 000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. After exclusion of an underlying disease and other risk factors, cholestasis resolved after treatment with ursodeoxycholic acid, a red blood cell transfusion, and intravenous immunoglobulins. This case is presented to create awareness for a more severe course of ABO HDFN in nonwhite and non-European mother-child pairs.
AB - ABO blood group incompatibility between mother and fetus can lead to hemolytic disease of the fetus and newborn (HDFN). We present the first case of severe O/A HDFN associated with extremely high-titer (1:32 000) immunoglobulin G anti-A antibodies in a Cameroon mother. Cord blood analysis revealed severe fetal hemolytic anemia and conjugated hyperbilirubinemia. After exclusion of an underlying disease and other risk factors, cholestasis resolved after treatment with ursodeoxycholic acid, a red blood cell transfusion, and intravenous immunoglobulins. This case is presented to create awareness for a more severe course of ABO HDFN in nonwhite and non-European mother-child pairs.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85064200084&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30872329
U2 - https://doi.org/10.1542/peds.2018-2859
DO - https://doi.org/10.1542/peds.2018-2859
M3 - Article
C2 - 30872329
SN - 0031-4005
VL - 143
JO - Pediatrics
JF - Pediatrics
IS - 4
M1 - e20182859
ER -