Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

Nina M. van Sorge; W.-Ludo van der Pol; Marc D. Jansen; Karin P. W. Geleijns; Sandra Kalmijn; Richard A. C. Hughes; Jeremy H. Rees; Jane Pritchard; Christian A. Vedeler; Kjell-Morten Myhr; Chris Shaw; Ivo N. van Schaik; John H. J. Wokke; Pieter A. van Doorn; Bart C. Jacobs; Jan G. J. van de Winkel; Leonard H. van den Berg

doi:https://doi.org/10.1016/j.jneuroim.2005.01.016

Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

Nina M. van Sorge, W.-Ludo van der Pol, Marc D. Jansen, Karin P. W. Geleijns, Sandra Kalmijn, Richard A. C. Hughes, Jeremy H. Rees, Jane Pritchard, Christian A. Vedeler, Kjell-Morten Myhr, Chris Shaw, Ivo N. van Schaik, John H. J. Wokke, Pieter A. van Doorn, Bart C. Jacobs, Jan G. J. van de Winkel, Leonard H. van den Berg

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS

Original language	English
Pages (from-to)	157-164
Journal	Journal of Neuroimmunology
Volume	162
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2005.01.016
Publication status	Published - 2005

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https://doi.org/10.1016/j.jneuroim.2005.01.016

Cite this

van Sorge, N. M., van der Pol, W. .-L., Jansen, M. D., Geleijns, K. P. W., Kalmijn, S., Hughes, R. A. C., Rees, J. H., Pritchard, J., Vedeler, C. A., Myhr, K.-M., Shaw, C., van Schaik, I. N., Wokke, J. H. J., van Doorn, P. A., Jacobs, B. C., van de Winkel, J. G. J., & van den Berg, L. H. (2005). Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms. Journal of Neuroimmunology, 162(1-2), 157-164. https://doi.org/10.1016/j.jneuroim.2005.01.016

@article{b931e11c76fb4c7fb3b3a06e78f19c13,

title = "Severity of Guillain-Barr{\'e} syndrome is associated with Fc gamma Receptor III polymorphisms",

abstract = "Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS",

author = "{van Sorge}, {Nina M.} and {van der Pol}, W.-Ludo and Jansen, {Marc D.} and Geleijns, {Karin P. W.} and Sandra Kalmijn and Hughes, {Richard A. C.} and Rees, {Jeremy H.} and Jane Pritchard and Vedeler, {Christian A.} and Kjell-Morten Myhr and Chris Shaw and {van Schaik}, {Ivo N.} and Wokke, {John H. J.} and {van Doorn}, {Pieter A.} and Jacobs, {Bart C.} and {van de Winkel}, {Jan G. J.} and {van den Berg}, {Leonard H.}",

year = "2005",

doi = "https://doi.org/10.1016/j.jneuroim.2005.01.016",

language = "English",

volume = "162",

pages = "157--164",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

van Sorge, NM, van der Pol, W-L, Jansen, MD, Geleijns, KPW, Kalmijn, S, Hughes, RAC, Rees, JH, Pritchard, J, Vedeler, CA, Myhr, K-M, Shaw, C, van Schaik, IN, Wokke, JHJ, van Doorn, PA, Jacobs, BC, van de Winkel, JGJ & van den Berg, LH 2005, 'Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms', Journal of Neuroimmunology, vol. 162, no. 1-2, pp. 157-164. https://doi.org/10.1016/j.jneuroim.2005.01.016

TY - JOUR

T1 - Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms

AU - van Sorge, Nina M.

AU - van der Pol, W.-Ludo

AU - Jansen, Marc D.

AU - Geleijns, Karin P. W.

AU - Kalmijn, Sandra

AU - Hughes, Richard A. C.

AU - Rees, Jeremy H.

AU - Pritchard, Jane

AU - Vedeler, Christian A.

AU - Myhr, Kjell-Morten

AU - Shaw, Chris

AU - van Schaik, Ivo N.

AU - Wokke, John H. J.

AU - van Doorn, Pieter A.

AU - Jacobs, Bart C.

AU - van de Winkel, Jan G. J.

AU - van den Berg, Leonard H.

PY - 2005

Y1 - 2005

N2 - Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS

AB - Macrophages and ganglioside-specific IgG are involved in the pathogenesis of Guillain-Barre syndrome (GBS). Leukocyte IgG receptors (Fc gammaR) confer potent cellular effector functions to the specificity of IgG. The efficacy of IgG-mediated cellular inflammatory responses is determined by functional polymorphisms of three Fc gammaR subclasses (Fc gammaRIIa: H131/R131; Fc gammaRIIIa: V158/F158; Fc gammaRIIIb: NA1/NA2). Fc gammaR genotype distributions were determined in a Dutch, and British cohort of GBS patients and controls. In addition, a meta-analysis incorporating all previously published data, encompassing a total of 345 GBS patients and 714 healthy controls, was performed. Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS

U2 - https://doi.org/10.1016/j.jneuroim.2005.01.016

DO - https://doi.org/10.1016/j.jneuroim.2005.01.016

M3 - Article

C2 - 15833371

SN - 0165-5728

VL - 162

SP - 157

EP - 164

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

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