TY - JOUR
T1 - Sex differences in disease activity and efficacy of treatment in spondyloarthritis
T2 - is body composition the cause?
AU - Ibáñez Vodnizza, Sebastián
AU - van der Horst-Bruinsma, Irene
PY - 2020/7/1
Y1 - 2020/7/1
N2 - PURPOSE OF REVIEW: The body composition and fat distribution is different between men and women, with different levels of circulating adipokines. These differences become more evident when suffering from an inflammatory disease, such as spondyloarthritris. In this review, we will explore the influence of obesity, body composition and adipokines on the differences in disease activity, progression and response to treatment, between men and women with spondyloarthritis. RECENT FINDINGS: Obesity, mainly determined by the body fat content, which is higher in women, is related to worse disease activity scores. Men with higher disease activity lose more muscle mass than women. Leptin, which is usually found at higher levels in overweight women, seems to be associated with greater spinal radiographic progression when it rises during the course of the disease. Being a woman and obesity, mainly because of the body fat content, are related to a worse response to TNF-α blockers. SUMMARY: Overlooking biological sex variation in body composition, circulating adipokines and hormonal levels, and the subsequent differences in clinical presentation, may ultimately hamper clinical treatment.
AB - PURPOSE OF REVIEW: The body composition and fat distribution is different between men and women, with different levels of circulating adipokines. These differences become more evident when suffering from an inflammatory disease, such as spondyloarthritris. In this review, we will explore the influence of obesity, body composition and adipokines on the differences in disease activity, progression and response to treatment, between men and women with spondyloarthritis. RECENT FINDINGS: Obesity, mainly determined by the body fat content, which is higher in women, is related to worse disease activity scores. Men with higher disease activity lose more muscle mass than women. Leptin, which is usually found at higher levels in overweight women, seems to be associated with greater spinal radiographic progression when it rises during the course of the disease. Being a woman and obesity, mainly because of the body fat content, are related to a worse response to TNF-α blockers. SUMMARY: Overlooking biological sex variation in body composition, circulating adipokines and hormonal levels, and the subsequent differences in clinical presentation, may ultimately hamper clinical treatment.
KW - body composition
KW - gender
KW - obesity
KW - sex
KW - spondyloarthritis
UR - http://www.scopus.com/inward/record.url?scp=85085586371&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/BOR.0000000000000717
DO - https://doi.org/10.1097/BOR.0000000000000717
M3 - Review article
C2 - 32453036
SN - 1040-8711
VL - 32
SP - 337
EP - 342
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
IS - 4
ER -