TY - JOUR
T1 - Sex differences in the neuroanatomy of alcohol dependence
T2 - hippocampus and amygdala subregions in a sample of 966 people from the ENIGMA Addiction Working Group
AU - ENIGMA Addiction Working Group
AU - Grace, Sally
AU - Rossetti, Maria Gloria
AU - Allen, Nicholas
AU - Batalla, Albert
AU - Bellani, Marcella
AU - Brambilla, Paolo
AU - Chye, Yann
AU - Cousijn, Janna
AU - Goudriaan, Anna E.
AU - Hester, Robert
AU - Hutchison, Kent
AU - Labuschagne, Izelle
AU - Momenan, Reza
AU - Martin-Santos, Rocio
AU - Rendell, Peter
AU - Solowij, Nadia
AU - Sinha, Rajita
AU - Li, Chiang shan Ray
AU - Schmaal, Lianne
AU - Sjoerds, Zsuzsika
AU - Suo, Chao
AU - Terrett, Gill
AU - van Holst, Ruth J.
AU - Veltman, Dick J.
AU - Yücel, Murat
AU - Thompson, Paul
AU - Conrod, Patricia
AU - Mackey, Scott
AU - Garavan, Hugh
AU - Lorenzetti, Valentina
N1 - Funding Information: Paul Thomson received grant support from Biogen, Inc., for work unrelated to this manuscript. Funding Information: We thank Diny Thomson, Danielle Tichelaar, Emily Robinson, Emily Watt, Iris Starcheus, Jamie Gladwell, John Tzaferis, Kirsty Kearney, and Simone Mizzi for their significant contributions to the image quality checks. We thank Preveetha Patalay for her helpful contributions to the statistical modelling; Philip Saemann for providing comments on code to generate the images for visual inspection; and Juan Dominguez for his helpful comments on the code to perform the FreeSurfer segmentation. This work was supported by the MASSIVE HPC facility (www.massive.org.au). This work was also supported by funding from the U.S. National Institute of Health (NIH R01DA047119) and the U.S. National Institute of Mental Health (NIH/NIMH R01MH116147). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in humans with alcohol dependence as most neuroimaging studies have been conducted in males. We examined hippocampal and amygdala subregions in a large sample of 966 people from the ENIGMA Addiction Working Group. This comprised 643 people with alcohol dependence (225 females), and a comparison group of 323 people without alcohol dependence (98 females). Males with alcohol dependence had smaller volumes of the total amygdala and its basolateral nucleus than male controls, that exacerbated with alcohol dose. Alcohol dependence was also associated with smaller volumes of the hippocampus and its CA1 and subiculum subfield volumes in both males and females. In summary, hippocampal and amygdalar subregions may be sensitive to both shared and distinct mechanisms in alcohol-dependent males and females.
AB - Males and females with alcohol dependence have distinct mental health and cognitive problems. Animal models of addiction postulate that the underlying neurobiological mechanisms are partially distinct, but there is little evidence of sex differences in humans with alcohol dependence as most neuroimaging studies have been conducted in males. We examined hippocampal and amygdala subregions in a large sample of 966 people from the ENIGMA Addiction Working Group. This comprised 643 people with alcohol dependence (225 females), and a comparison group of 323 people without alcohol dependence (98 females). Males with alcohol dependence had smaller volumes of the total amygdala and its basolateral nucleus than male controls, that exacerbated with alcohol dose. Alcohol dependence was also associated with smaller volumes of the hippocampus and its CA1 and subiculum subfield volumes in both males and females. In summary, hippocampal and amygdalar subregions may be sensitive to both shared and distinct mechanisms in alcohol-dependent males and females.
UR - http://www.scopus.com/inward/record.url?scp=85102027585&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41398-021-01204-1
DO - https://doi.org/10.1038/s41398-021-01204-1
M3 - Article
C2 - 33664226
SN - 2158-3188
VL - 11
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 156
ER -