TY - JOUR
T1 - Sex hormones and cognitive decline in elderly men
AU - Muller, Majon
AU - van den Beld, Annewieke W.
AU - Grobbee, Diederick E.
AU - de Jong, Frank H.
AU - Lamberts, Steven W.J.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function.
AB - Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function.
KW - Cognition
KW - Estradiol
KW - Testosterone
UR - http://www.scopus.com/inward/record.url?scp=57649173619&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.psyneuen.2008.08.008
DO - https://doi.org/10.1016/j.psyneuen.2008.08.008
M3 - Article
C2 - 18845400
SN - 0306-4530
VL - 34
SP - 27
EP - 31
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
IS - 1
ER -