TY - JOUR
T1 - Sexual dimorphism in the prevalence, manifestation and outcomes of axial spondyloarthritis
AU - Stovall, Rachael
AU - van der Horst-Bruinsma, Irene E.
AU - Liu, Shao-Hsien
AU - Rusman, Tamara
AU - Gensler, Lianne S.
N1 - Funding Information: I.E.v.d.H.-B. has received honoraria, consultancy fees and/or research grants from AbbVie, Eli Lilly, BMS, MSD, Novartis, Pfizer and UCB Pharma. L.S.G. has received consultancy fees from AbbVie, Eli Lilly, Gilead, GSK, Janssen, Novartis, Pfizer and UCB, and research grants from Pfizer. T.R. has received research funding from Pfizer. The remaining authors declare no competing interests. Funding Information: This work was supported by a charitable contribution to the UMass Memorial Foundation from Timothy S. and Elaine L. Peterson (S.H.L.), by the SAA/Jane Bruckel Early Career Investigator in AxSpA Award (S.H.L.), and by the National Center for Advancing Translational Sciences, NIH, through UCSF-CTSI Grant Number TL1 TR001871 (R.S.). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Publisher Copyright: © 2022, This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
PY - 2022/11
Y1 - 2022/11
N2 - Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that predominantly affects the axial skeleton, although it can affect peripheral joints, and extra-musculoskeletal manifestations also occur. Historically, axSpA was thought to be a disease predominantly seen in men, although with the advent of magnetic resonance imaging techniques and advances in research, this dogma has been challenged and refuted. Sex and gender are different concepts, and both can have a role in disease. In axSpA, consideration of the influence of sex and gender on the disease phenotype is necessary to predict outcomes and to enable the development of therapeutic approaches that are best suited to individual patients.
AB - Axial spondyloarthritis (axSpA) is a chronic inflammatory disease that predominantly affects the axial skeleton, although it can affect peripheral joints, and extra-musculoskeletal manifestations also occur. Historically, axSpA was thought to be a disease predominantly seen in men, although with the advent of magnetic resonance imaging techniques and advances in research, this dogma has been challenged and refuted. Sex and gender are different concepts, and both can have a role in disease. In axSpA, consideration of the influence of sex and gender on the disease phenotype is necessary to predict outcomes and to enable the development of therapeutic approaches that are best suited to individual patients.
UR - http://www.scopus.com/inward/record.url?scp=85138224704&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41584-022-00833-0
DO - https://doi.org/10.1038/s41584-022-00833-0
M3 - Review article
C2 - 36109666
SN - 1759-4790
VL - 18
SP - 657
EP - 669
JO - Nature Reviews Rheumatology
JF - Nature Reviews Rheumatology
IS - 11
ER -