TY - JOUR
T1 - Short-course whole-brain radiotherapy (WBRT) for brain metastases due to small-cell lung cancer (SCLC)
AU - Bohlen, Guenther
AU - Meyners, Thekla
AU - Kieckebusch, Susanne
AU - Lohynska, Radka
AU - Veninga, Theo
AU - Stalpers, Lukas J. A.
AU - Schild, Steven E.
AU - Rades, Dirk
PY - 2010
Y1 - 2010
N2 - Many patients with brain metastases due to SCLC have a poor survival prognosis. The most common treatment is whole-brain radiotherapy (WBRT). This retrospective study compares short-course WBRT with 5x4Gy in 1 week to standard WBRT with 10x3Gy in 2 weeks. Forty-four SCLC patients receiving WBRT with 5x4Gy were compared to 102 patients receiving 10x3Gy for survival (OS) and local (intracerebral) control (LC). Seven further potential prognostic factors were investigated: age, gender, Karnofsky Performance Score (KPS), number of brain metastases, extracerebral metastases, interval from tumor diagnosis to WBRT, RPA (Recursive Partitioning Analysis) class. After 5x4Gy, 12-month OS was 15%, versus 22% after 10x3Gy (p=0.69). On multivariate analysis, improved OS was associated with age or=70 (p <0.001), <4 brain metastases (p=0.011), and RPA class 1 (p <0.001). 12-month LC was 34% after 5x4Gy versus 25% after 10x3Gy (p=0.32). On multivariate analysis, improved LC was associated with KPS >or=70 (p <0.001), <4 brain metastases (p=0.027), and RPA class 1 (p <0.001). In patients with brain metastases due to SCLC, short-course WBRT with 5x4Gy provided similar outcomes as 10x3Gy and appears preferable, particularly for patients with poor estimated survival
AB - Many patients with brain metastases due to SCLC have a poor survival prognosis. The most common treatment is whole-brain radiotherapy (WBRT). This retrospective study compares short-course WBRT with 5x4Gy in 1 week to standard WBRT with 10x3Gy in 2 weeks. Forty-four SCLC patients receiving WBRT with 5x4Gy were compared to 102 patients receiving 10x3Gy for survival (OS) and local (intracerebral) control (LC). Seven further potential prognostic factors were investigated: age, gender, Karnofsky Performance Score (KPS), number of brain metastases, extracerebral metastases, interval from tumor diagnosis to WBRT, RPA (Recursive Partitioning Analysis) class. After 5x4Gy, 12-month OS was 15%, versus 22% after 10x3Gy (p=0.69). On multivariate analysis, improved OS was associated with age or=70 (p <0.001), <4 brain metastases (p=0.011), and RPA class 1 (p <0.001). 12-month LC was 34% after 5x4Gy versus 25% after 10x3Gy (p=0.32). On multivariate analysis, improved LC was associated with KPS >or=70 (p <0.001), <4 brain metastases (p=0.027), and RPA class 1 (p <0.001). In patients with brain metastases due to SCLC, short-course WBRT with 5x4Gy provided similar outcomes as 10x3Gy and appears preferable, particularly for patients with poor estimated survival
U2 - https://doi.org/10.1016/j.clineuro.2009.11.004
DO - https://doi.org/10.1016/j.clineuro.2009.11.004
M3 - Article
C2 - 19962229
SN - 0303-8467
VL - 112
SP - 183
EP - 187
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 3
ER -