TY - JOUR
T1 - Short report
T2 - Toll-like receptor 4 polymorphisms in dengue virus-infected children
AU - Djamiatun, Kis
AU - Ferwerda, Bart
AU - Netea, Mihai G.
AU - Van Der Ven, André J.A.M.
AU - Dolmans, Wil M.V.
AU - Faradz, Sultana M.H.
PY - 2011/8
Y1 - 2011/8
N2 - Differential viral recognition by cells bearing Toll-like receptor 4 (TLR4) polymorphisms Asp299Gly and Thr399Ile may influence susceptibility and severity of dengue virus infection. In central Java, Indonesia, we investigated 201 children with dengue hemorrhagic fever (DHF) and 179 healthy controls. Patients and controls were mostly ethnic Javanese. A nearly complete cosegregation of the two mutations was observed. The TLR4 299/399 genotype was found in five patients and four controls. Prevalence of the TLR4 299/399 genotype did not differ significantly between controls and DHF patients or between patients with different severities of DHF. Also, vascular leakage in patients with different TLR4 genotypes did not differ. Thus, the 299/399 TLR4 haplotype has only minor influence on susceptibility and severity of complicated dengue virus infection.
AB - Differential viral recognition by cells bearing Toll-like receptor 4 (TLR4) polymorphisms Asp299Gly and Thr399Ile may influence susceptibility and severity of dengue virus infection. In central Java, Indonesia, we investigated 201 children with dengue hemorrhagic fever (DHF) and 179 healthy controls. Patients and controls were mostly ethnic Javanese. A nearly complete cosegregation of the two mutations was observed. The TLR4 299/399 genotype was found in five patients and four controls. Prevalence of the TLR4 299/399 genotype did not differ significantly between controls and DHF patients or between patients with different severities of DHF. Also, vascular leakage in patients with different TLR4 genotypes did not differ. Thus, the 299/399 TLR4 haplotype has only minor influence on susceptibility and severity of complicated dengue virus infection.
UR - http://www.scopus.com/inward/record.url?scp=80051542367&partnerID=8YFLogxK
U2 - https://doi.org/10.4269/ajtmh.2011.10-0728
DO - https://doi.org/10.4269/ajtmh.2011.10-0728
M3 - Article
C2 - 21813858
SN - 0002-9637
VL - 85
SP - 352
EP - 354
JO - American journal of tropical medicine and hygiene
JF - American journal of tropical medicine and hygiene
IS - 2
ER -