TY - JOUR
T1 - Should antifibrinolytics be given in all patients with trauma?
AU - Levi, Marcel
PY - 2012
Y1 - 2012
N2 - Purpose of review Hemorrhage is the second most important cause of death in patients with trauma, contributing to approximately 30% of trauma-related mortality. Pharmacological prohemostatic agents may be useful adjunctive treatment options in patients with severe blood loss. Recent findings Tranexamic acid was evaluated in a large international randomized controlled study in patients with trauma and severe blood loss. The drug was shown to reduce death due to bleeding, provided the treatment was given within 3 h after injury. Tranexamic acid treatment did not result in serious adverse events nor thrombotic complications. Summary In view of this efficacy and safety of this relatively cheap and simple drug, it may be recommended to put tranexamic acid in the first (maybe even prehospital) line of management of patients with severe traumatic hemorrhage
AB - Purpose of review Hemorrhage is the second most important cause of death in patients with trauma, contributing to approximately 30% of trauma-related mortality. Pharmacological prohemostatic agents may be useful adjunctive treatment options in patients with severe blood loss. Recent findings Tranexamic acid was evaluated in a large international randomized controlled study in patients with trauma and severe blood loss. The drug was shown to reduce death due to bleeding, provided the treatment was given within 3 h after injury. Tranexamic acid treatment did not result in serious adverse events nor thrombotic complications. Summary In view of this efficacy and safety of this relatively cheap and simple drug, it may be recommended to put tranexamic acid in the first (maybe even prehospital) line of management of patients with severe traumatic hemorrhage
U2 - https://doi.org/10.1097/ACO.0b013e3283532b29
DO - https://doi.org/10.1097/ACO.0b013e3283532b29
M3 - Editorial
C2 - 22459985
SN - 0952-7907
VL - 25
SP - 385
EP - 388
JO - Current opinion in anaesthesiology
JF - Current opinion in anaesthesiology
IS - 3
ER -