Sibling history is associated with heart failure after a first myocardial infarction

Charlotte Glinge, Louise Oestergaard, Reza Jabbari, Sara Rossetti, Regitze Skals, Lars Køber, Thomas Engstrøm, Connie R. Bezzina, Christian Torp-Pedersen, Gunnar Gislason, Jacob Tfelt-Hansen

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Abstract

Objective Morbidity and mortality due to heart failure (HF) as a complication of myocardial infarction (MI) is high, and remains among the leading causes of death and hospitalisation. This study investigated the association between family history of MI with or without HF, and the risk of developing HF after first MI. Methods Through nationwide registries, we identified all individuals aged 18-50 years hospitalised with first MI from 1997 to 2016 in Denmark. We identified 13 810 patients with MI, and the cohort was followed until HF diagnosis, second MI, 3 years after index MI, emigration, death or the end of 2016, whichever occurred first. HRs were estimated by Cox hazard regression models adjusted for sex, age, calendar year and comorbidities (reference: patients with no family history of MI). Results After adjustment, we observed an increased risk of MI-induced HF for those having a sibling with MI with HF (HR 2.05, 95% CI 1.02 to 4.12). Those having a sibling with MI without HF also had a significant, but lower increased risk of HF (HR 1.39, 95% CI 1.05 to 1.84). Parental history of MI with or without HF was not associated with HF. Conclusion In this nationwide cohort, sibling history of MI with or without HF was associated with increased risk of HF after first MI, while a parental family history was not, suggesting that shared environmental factors may predominate in the determination of risk for developing HF.
Original languageEnglish
Article numbere001143
JournalOpen Heart
Volume7
Issue number1
DOIs
Publication statusPublished - 24 Mar 2020

Keywords

  • family history
  • heart failure
  • myocardial ischaemia and infarction (IHD)

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