TY - JOUR
T1 - Similar effect of autologous and allogeneic cell therapy for ischemic heart disease: Systematic review and meta-analysis of large animal studies
AU - Jansen Of Lorkeers, Sanne Johanna
AU - Eding, Joep Egbert Coenraad
AU - Vesterinen, Hanna Mikaela
AU - van der Spoel, Tycho Ids Gijsbert
AU - Sena, Emily Shamiso
AU - Duckers, Henricus Johannes
AU - Doevendans, Pieter Adrianus
AU - Macleod, Malcolm Robert
AU - Chamuleau, Steven Anton Jozef
PY - 2015/1/2
Y1 - 2015/1/2
N2 - Rationale: In regenerative therapy for ischemic heart disease, use of both autologous and allogeneic stem cells has been investigated. Autologous cell can be applied without immunosuppression, but availability is restricted, and cells have been exposed to risk factors and aging. Allogeneic cell therapy enables preoperative production of potent cell lines and immediate availability of cell products, allowing off-the-shelf therapy. It is unknown which cell source is preferred with regard to improving cardiac function. Objective: We performed a meta-analysis of preclinical data of cell therapy for ischemic heart disease. Methods and results: We conducted a systematic literature search to identify publications describing controlled preclinical trials of unmodified stem cell therapy in large animal models of myocardial ischemia. Data from 82 studies involving 1415 animals showed a significant improvement in mean left ventricular ejection fraction in treated compared with control animals (8.3%, 95% confidence interval, 7.1-9.5; P<0.001). Meta-regression revealed a similar difference in left ventricular ejection fraction in autologous (8.8%, 95% confidence interval, 7.3-10.3; n=981) and allogeneic (7.3%, 95% confidence interval, 4.4-10.2, n=331; P=0.3) cell therapies. Conclusions: Autologous and allogeneic cell therapy for ischemic heart disease show a similar improvement in left ventricular ejection fraction in large animal models of myocardial ischemia, compared with placebo. These results are important for the design of future clinical trials.
AB - Rationale: In regenerative therapy for ischemic heart disease, use of both autologous and allogeneic stem cells has been investigated. Autologous cell can be applied without immunosuppression, but availability is restricted, and cells have been exposed to risk factors and aging. Allogeneic cell therapy enables preoperative production of potent cell lines and immediate availability of cell products, allowing off-the-shelf therapy. It is unknown which cell source is preferred with regard to improving cardiac function. Objective: We performed a meta-analysis of preclinical data of cell therapy for ischemic heart disease. Methods and results: We conducted a systematic literature search to identify publications describing controlled preclinical trials of unmodified stem cell therapy in large animal models of myocardial ischemia. Data from 82 studies involving 1415 animals showed a significant improvement in mean left ventricular ejection fraction in treated compared with control animals (8.3%, 95% confidence interval, 7.1-9.5; P<0.001). Meta-regression revealed a similar difference in left ventricular ejection fraction in autologous (8.8%, 95% confidence interval, 7.3-10.3; n=981) and allogeneic (7.3%, 95% confidence interval, 4.4-10.2, n=331; P=0.3) cell therapies. Conclusions: Autologous and allogeneic cell therapy for ischemic heart disease show a similar improvement in left ventricular ejection fraction in large animal models of myocardial ischemia, compared with placebo. These results are important for the design of future clinical trials.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84920823059&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/25186794
U2 - https://doi.org/10.1161/CIRCRESAHA.116.304872
DO - https://doi.org/10.1161/CIRCRESAHA.116.304872
M3 - Article
C2 - 25186794
SN - 0009-7330
VL - 116
SP - 80
EP - 86
JO - Circulation Research
JF - Circulation Research
IS - 1
ER -