Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Giacomo Biagiotti; Gianluca Toniolo; Martin Albino; Mirko Severi; Patrizia Andreozzi; Marcello Marelli; Hana Kokot; Giancarlo Tria; Annalisa Guerri; Claudio Sangregorio; Javier Rojo; Debora Berti; Marco Marradi; Stefano Cicchi; Iztok Urbančič; Yvette van Kooyk; Fabrizio Chiodo; Barbara Richichi

doi:https://doi.org/10.1039/d3nh00063j

Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Giacomo Biagiotti, Gianluca Toniolo, Martin Albino, Mirko Severi, Patrizia Andreozzi, Marcello Marelli, Hana Kokot, Giancarlo Tria, Annalisa Guerri, Claudio Sangregorio, Javier Rojo, Debora Berti, Marco Marradi, Stefano Cicchi, Iztok Urbančič, Yvette van Kooyk, Fabrizio Chiodo, Barbara Richichi

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Abstract

Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

Original language	English
Pages (from-to)	776-782
Number of pages	7
Journal	Nanoscale Horizons
Volume	8
Issue number	6
Early online date	2023
DOIs	https://doi.org/10.1039/d3nh00063j
Publication status	Published - 15 Mar 2023

Access to Document

https://doi.org/10.1039/d3nh00063j

Cite this

Biagiotti, G., Toniolo, G., Albino, M., Severi, M., Andreozzi, P., Marelli, M., Kokot, H., Tria, G., Guerri, A., Sangregorio, C., Rojo, J., Berti, D., Marradi, M., Cicchi, S., Urbančič, I., van Kooyk, Y., Chiodo, F., & Richichi, B. (2023). Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties. Nanoscale Horizons, 8(6), 776-782. https://doi.org/10.1039/d3nh00063j

@article{9cc0ff946fc144aebf8eafe202dd0d98,

title = "Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties",

abstract = "Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.",

author = "Giacomo Biagiotti and Gianluca Toniolo and Martin Albino and Mirko Severi and Patrizia Andreozzi and Marcello Marelli and Hana Kokot and Giancarlo Tria and Annalisa Guerri and Claudio Sangregorio and Javier Rojo and Debora Berti and Marco Marradi and Stefano Cicchi and Iztok Urban{\v c}i{\v c} and {van Kooyk}, Yvette and Fabrizio Chiodo and Barbara Richichi",

note = "Funding Information: G. B., F. C. M. M., and B. R., thank COST Action CA18103 INNOGLY: Innovation with glycans: new frontiers from synthesis to new biological targets. G. B. G. T., M. A., M. S., P. A., G. T., A. G., D. B., C. S., M. M., S. C. and B. R. thank MIUR-Italy (“Progetto Dipartimenti di Eccellenza 2018–2022”, allocated to the Department of Chemistry “Ugo Schiff”). We acknowledge the Florence Center for Electron Nanoscopy (FloCEN) at the University of Florence. G. B. and B. R. thank Fondazione Umberto Veronesi for supporting the post-doctoral fellowship of G. B. (Grant numbers: 4731, 4451 and 5167). B. R. thanks L{\textquoteright}Amore di Matteo Coveri ONLUS for financial support. J. R. acknowledges a grant from MCIN/AEI/10.13039/501100011033 (PID2020-118403GB-I00). I. U. and H. K. thank the Slovenian Research Agency (P1-0060) for financial support. Publisher Copyright: {\textcopyright} 2023 The Royal Society of Chemistry.",

year = "2023",

month = mar,

day = "15",

doi = "https://doi.org/10.1039/d3nh00063j",

language = "English",

volume = "8",

pages = "776--782",

journal = "Nanoscale Horizons",

issn = "2055-6756",

publisher = "Royal Society of Chemistry",

number = "6",

}

Biagiotti, G, Toniolo, G, Albino, M, Severi, M, Andreozzi, P, Marelli, M, Kokot, H, Tria, G, Guerri, A, Sangregorio, C, Rojo, J, Berti, D, Marradi, M, Cicchi, S, Urbančič, I, van Kooyk, Y , Chiodo, F & Richichi, B 2023, 'Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties', Nanoscale Horizons, vol. 8, no. 6, pp. 776-782. https://doi.org/10.1039/d3nh00063j

TY - JOUR

T1 - Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

AU - Biagiotti, Giacomo

AU - Toniolo, Gianluca

AU - Albino, Martin

AU - Severi, Mirko

AU - Andreozzi, Patrizia

AU - Marelli, Marcello

AU - Kokot, Hana

AU - Tria, Giancarlo

AU - Guerri, Annalisa

AU - Sangregorio, Claudio

AU - Rojo, Javier

AU - Berti, Debora

AU - Marradi, Marco

AU - Cicchi, Stefano

AU - Urbančič, Iztok

AU - van Kooyk, Yvette

AU - Chiodo, Fabrizio

AU - Richichi, Barbara

N1 - Funding Information: G. B., F. C. M. M., and B. R., thank COST Action CA18103 INNOGLY: Innovation with glycans: new frontiers from synthesis to new biological targets. G. B. G. T., M. A., M. S., P. A., G. T., A. G., D. B., C. S., M. M., S. C. and B. R. thank MIUR-Italy (“Progetto Dipartimenti di Eccellenza 2018–2022”, allocated to the Department of Chemistry “Ugo Schiff”). We acknowledge the Florence Center for Electron Nanoscopy (FloCEN) at the University of Florence. G. B. and B. R. thank Fondazione Umberto Veronesi for supporting the post-doctoral fellowship of G. B. (Grant numbers: 4731, 4451 and 5167). B. R. thanks L’Amore di Matteo Coveri ONLUS for financial support. J. R. acknowledges a grant from MCIN/AEI/10.13039/501100011033 (PID2020-118403GB-I00). I. U. and H. K. thank the Slovenian Research Agency (P1-0060) for financial support. Publisher Copyright: © 2023 The Royal Society of Chemistry.

PY - 2023/3/15

Y1 - 2023/3/15

N2 - Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

AB - Cellulose nanocrystal and gold nanoparticles are assembled, in a unique way, to yield a novel modular glyconanomaterial whose surface is then easily engineered with one or two different headgroups, by exploiting a robust click chemistry route. We demonstrate the potential of this approach by conjugating monosaccharide headgroups to the glyconanomaterial and show that the sugars retain their binding capability to C-type lectin receptors, as also directly visualized by cryo-TEM.

UR - http://www.scopus.com/inward/record.url?scp=85151861768&partnerID=8YFLogxK

U2 - https://doi.org/10.1039/d3nh00063j

DO - https://doi.org/10.1039/d3nh00063j

M3 - Article

C2 - 36951189

SN - 2055-6756

VL - 8

SP - 776

EP - 782

JO - Nanoscale Horizons

JF - Nanoscale Horizons

IS - 6

ER -

Simple engineering of hybrid cellulose nanocrystal-gold nanoparticles results in a functional glyconanomaterial with biomolecular recognition properties

Abstract

Access to Document

Other files and links

Cite this