Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

E. Mazzone; F. Bianco; M. Main; M. van den Hauwe; M. Ash; R. de Vries; J. Fagoaga Mata; S. Stein; R. de Sanctis; A. D'Amico; C. Palermo; L. Fanelli; M. C. Scoto; A. Mayhew; M. Eagle; M. Vigo; A. Febrer; R. Korinthenberg; M. de Visser; K. Bushby; F. Muntoni; N. Goemans; M. P. Sormani; E. Bertini; M. Pane; E. Mercuri

doi:https://doi.org/10.1016/j.nmd.2013.06.001

Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

E. Mazzone, F. Bianco, M. Main, M. van den Hauwe, M. Ash, R. de Vries, J. Fagoaga Mata, S. Stein, R. de Sanctis, A. D'Amico, C. Palermo, L. Fanelli, M. C. Scoto, A. Mayhew, M. Eagle, M. Vigo, A. Febrer, R. Korinthenberg, M. de Visser, K. BushbyF. Muntoni, N. Goemans, M. P. Sormani, E. Bertini, M. Pane, E. Mercuri

Neurology (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Abstract

The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients

Original language	English
Pages (from-to)	624-628
Journal	Neuromuscular disorders
Volume	23
Issue number	8
DOIs	https://doi.org/10.1016/j.nmd.2013.06.001
Publication status	Published - 2013

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https://doi.org/10.1016/j.nmd.2013.06.001

Cite this

Mazzone, E., Bianco, F., Main, M., van den Hauwe, M., Ash, M., de Vries, R., Fagoaga Mata, J., Stein, S., de Sanctis, R., D'Amico, A., Palermo, C., Fanelli, L., Scoto, M. C., Mayhew, A., Eagle, M., Vigo, M., Febrer, A., Korinthenberg, R., de Visser, M., ... Mercuri, E. (2013). Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study. Neuromuscular disorders, 23(8), 624-628. https://doi.org/10.1016/j.nmd.2013.06.001

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title = "Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study",

abstract = "The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients",

author = "E. Mazzone and F. Bianco and M. Main and {van den Hauwe}, M. and M. Ash and {de Vries}, R. and {Fagoaga Mata}, J. and S. Stein and {de Sanctis}, R. and A. D'Amico and C. Palermo and L. Fanelli and Scoto, {M. C.} and A. Mayhew and M. Eagle and M. Vigo and A. Febrer and R. Korinthenberg and {de Visser}, M. and K. Bushby and F. Muntoni and N. Goemans and Sormani, {M. P.} and E. Bertini and M. Pane and E. Mercuri",

year = "2013",

doi = "https://doi.org/10.1016/j.nmd.2013.06.001",

language = "English",

volume = "23",

pages = "624--628",

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Mazzone, E, Bianco, F, Main, M, van den Hauwe, M, Ash, M, de Vries, R, Fagoaga Mata, J, Stein, S, de Sanctis, R, D'Amico, A, Palermo, C, Fanelli, L, Scoto, MC, Mayhew, A, Eagle, M, Vigo, M, Febrer, A, Korinthenberg, R, de Visser, M, Bushby, K, Muntoni, F, Goemans, N, Sormani, MP, Bertini, E, Pane, M & Mercuri, E 2013, 'Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study', Neuromuscular disorders, vol. 23, no. 8, pp. 624-628. https://doi.org/10.1016/j.nmd.2013.06.001

TY - JOUR

T1 - Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study

AU - Mazzone, E.

AU - Bianco, F.

AU - Main, M.

AU - van den Hauwe, M.

AU - Ash, M.

AU - de Vries, R.

AU - Fagoaga Mata, J.

AU - Stein, S.

AU - de Sanctis, R.

AU - D'Amico, A.

AU - Palermo, C.

AU - Fanelli, L.

AU - Scoto, M. C.

AU - Mayhew, A.

AU - Eagle, M.

AU - Vigo, M.

AU - Febrer, A.

AU - Korinthenberg, R.

AU - de Visser, M.

AU - Bushby, K.

AU - Muntoni, F.

AU - Goemans, N.

AU - Sormani, M. P.

AU - Bertini, E.

AU - Pane, M.

AU - Mercuri, E.

PY - 2013

Y1 - 2013

N2 - The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients

AB - The aim of our longitudinal multicentric study was to establish the changes on the 6min walk test (6MWT) in ambulant SMA type III children and adults over a 12month period. Thirty-eight ambulant type III patients performed the 6MWT at baseline and 12months after baseline. The distance covered in 6min ranged between 75 and 510m (mean 294.91, SD 127) at baseline and between 50 and 611m (mean 293.41m, SD 141) at 12months. The mean change in distance between baseline and 12months was -1.46 (SD 50.1; range: -183 to 131.8m). The changes were not correlated with age or baseline values (p>.05) even though younger patients reaching puberty, had a relatively higher risk of showing deterioration of more than 30m compared to older patients. Our findings provide the first longitudinal data using the 6MWT in ambulant SMA patients

U2 - https://doi.org/10.1016/j.nmd.2013.06.001

DO - https://doi.org/10.1016/j.nmd.2013.06.001

M3 - Article

C2 - 23809874

SN - 0960-8966

VL - 23

SP - 624

EP - 628

JO - Neuromuscular disorders

JF - Neuromuscular disorders

IS - 8

ER -