Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

Yvonne Van De Wal; Yvonne M C Kooy; Peter A. Van Veelen; Salvador A. Peña; Luisa M. Mearin; Øyvind Molberg; Knut E A Lundin; Ludvig M. Sollid; Tuna Mutis; Willemien E. Benckhuijsen; Jan Wouter Drijfhout; Frits Koning

doi:https://doi.org/10.1073/pnas.95.17.10050

Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

Yvonne Van De Wal, Yvonne M C Kooy, Peter A. Van Veelen, Salvador A. Peña, Luisa M. Mearin, Øyvind Molberg, Knut E A Lundin, Ludvig M. Sollid, Tuna Mutis, Willemien E. Benckhuijsen, Jan Wouter Drijfhout, Frits Koning

Research output: Contribution to journal › Article › Academic › peer-review

226 Citations (Scopus)

Abstract

Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients expresses the HLA-DQ2 and/or DQ8 molecules, and gluten-specific HLA-DQ-restricted T cells have been found at the site of the lesion in the gut. The nature of peptides that are recognized by such T cells, however, has been unclear so far. We now report the identification of a gliadin-derived epitope that dominantly is recognized by intestinal gluten-specific HLA-DQ8- restricted T cells. The characterization of such epitopes is a key step toward the development of strategies to interfere in mechanisms involved in the pathogenesis of celiac disease.

Original language	English
Pages (from-to)	10050-10054
Number of pages	5
Journal	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume	95
Issue number	17
DOIs	https://doi.org/10.1073/pnas.95.17.10050
Publication status	Published - 18 Aug 1998

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Van De Wal, Y., Kooy, Y. M. C., Van Veelen, P. A., Peña, S. A., Mearin, L. M., Molberg, Ø., Lundin, K. E. A., Sollid, L. M., Mutis, T., Benckhuijsen, W. E., Drijfhout, J. W., & Koning, F. (1998). Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 95(17), 10050-10054. https://doi.org/10.1073/pnas.95.17.10050

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title = "Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin",

abstract = "Celiac disease is a common severe intestinal disease resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients expresses the HLA-DQ2 and/or DQ8 molecules, and gluten-specific HLA-DQ-restricted T cells have been found at the site of the lesion in the gut. The nature of peptides that are recognized by such T cells, however, has been unclear so far. We now report the identification of a gliadin-derived epitope that dominantly is recognized by intestinal gluten-specific HLA-DQ8- restricted T cells. The characterization of such epitopes is a key step toward the development of strategies to interfere in mechanisms involved in the pathogenesis of celiac disease.",

author = "{Van De Wal}, Yvonne and Kooy, {Yvonne M C} and {Van Veelen}, {Peter A.} and Pe{\~n}a, {Salvador A.} and Mearin, {Luisa M.} and {\O}yvind Molberg and Lundin, {Knut E A} and Sollid, {Ludvig M.} and Tuna Mutis and Benckhuijsen, {Willemien E.} and Drijfhout, {Jan Wouter} and Frits Koning",

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pages = "10050--10054",

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Van De Wal, Y, Kooy, YMC, Van Veelen, PA, Peña, SA, Mearin, LM, Molberg, Ø, Lundin, KEA, Sollid, LM, Mutis, T, Benckhuijsen, WE, Drijfhout, JW & Koning, F 1998, 'Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, no. 17, pp. 10050-10054. https://doi.org/10.1073/pnas.95.17.10050

Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. / Van De Wal, Yvonne; Kooy, Yvonne M C; Van Veelen, Peter A. et al.
In: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 95, No. 17, 18.08.1998, p. 10050-10054.

Research output: Contribution to journal › Article › Academic › peer-review

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Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin

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