TY - JOUR
T1 - Small molecular compounds in development for rheumatoid arthritis
AU - van Vollenhoven, Ronald F.
PY - 2013
Y1 - 2013
N2 - Purpose of review To provide an update on the development of small molecular compounds as novel therapeutics for the treatment of rheumatoid arthritis. The development of such orally available agents has long been hoped for in rheumatology; in the past year, it has become clear that the expectations are becoming fulfilled. Recent findings Over the past year, a large number of clinical trials have been published or presented reporting positive therapeutic results with tyrosine kinase inhibitors, a large class of orally available drugs that are also being developed in other medical fields. This class of drugs includes the Janus kinase (JAK) inhibitors, and data on tofacitinib published during the past year have attested to the biologic-like efficacy of this drug and supported its subsequent U. S. Food and Drugs Administration (FDA) approval. Positive clinical trial results have also been reported for several other JAK inhibitors including baricitinib. Several other JAK inhibitors and other small molecular entities are also being developed in studies ranging from preclinical models to large clinical trials. Summary Tyrosine kinase inhibition has emerged as a major new direction in rheumatoid arthritis therapy
AB - Purpose of review To provide an update on the development of small molecular compounds as novel therapeutics for the treatment of rheumatoid arthritis. The development of such orally available agents has long been hoped for in rheumatology; in the past year, it has become clear that the expectations are becoming fulfilled. Recent findings Over the past year, a large number of clinical trials have been published or presented reporting positive therapeutic results with tyrosine kinase inhibitors, a large class of orally available drugs that are also being developed in other medical fields. This class of drugs includes the Janus kinase (JAK) inhibitors, and data on tofacitinib published during the past year have attested to the biologic-like efficacy of this drug and supported its subsequent U. S. Food and Drugs Administration (FDA) approval. Positive clinical trial results have also been reported for several other JAK inhibitors including baricitinib. Several other JAK inhibitors and other small molecular entities are also being developed in studies ranging from preclinical models to large clinical trials. Summary Tyrosine kinase inhibition has emerged as a major new direction in rheumatoid arthritis therapy
U2 - https://doi.org/10.1097/BOR.0b013e32835fd828
DO - https://doi.org/10.1097/BOR.0b013e32835fd828
M3 - Review article
C2 - 23492738
SN - 1040-8711
VL - 25
SP - 391
EP - 397
JO - Current Opinion in Rheumatology
JF - Current Opinion in Rheumatology
IS - 3
ER -