TY - JOUR
T1 - Small vessel disease lesion type and brain atrophy
T2 - The role of co-occurring amyloid
AU - TRACE‐VCI study group
AU - Heinen, Rutger
AU - Groeneveld, Onno N
AU - Barkhof, Frederik
AU - de Bresser, Jeroen
AU - Exalto, Lieza G
AU - Kuijf, Hugo J
AU - Prins, Niels D
AU - Scheltens, Philip
AU - van der Flier, Wiesje M
AU - Biessels, Geert Jan
N1 - © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.
PY - 2020
Y1 - 2020
N2 - Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation.Methods: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488).Results: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid-negative patients. SVD-related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid-negative patients.Discussion: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients.
AB - Introduction: It is unknown whether different types of small vessel disease (SVD), differentially relate to brain atrophy and if co-occurring Alzheimer's disease pathology affects this relation.Methods: In 725 memory clinic patients with SVD (mean age 67 ± 8 years, 48% female) we compared brain volumes of those with moderate/severe white matter hyperintensities (WMHs; n = 326), lacunes (n = 132) and cerebral microbleeds (n = 321) to a reference group with mild WMHs (n = 197), also considering cerebrospinal fluid (CSF) amyloid status in a subset of patients (n = 488).Results: WMHs and lacunes, but not cerebral microbleeds, were associated with smaller gray matter (GM) volumes. In analyses stratified by CSF amyloid status, WMHs and lacunes were associated with smaller total brain and GM volumes only in amyloid-negative patients. SVD-related atrophy was most evident in frontal (cortical) GM, again predominantly in amyloid-negative patients.Discussion: Amyloid status modifies the differential relation between SVD lesion type and brain atrophy in memory clinic patients.
KW - Alzheimer's disease
KW - brain atrophy
KW - cerebral microbleeds
KW - cerebral small vessel disease
KW - lacunes
KW - magnetic resonance imaging
KW - vascular cognitive impairment
KW - white matter hyperintensities
UR - http://www.scopus.com/inward/record.url?scp=85100510107&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/dad2.12060
DO - https://doi.org/10.1002/dad2.12060
M3 - Article
C2 - 32695872
SN - 2352-8729
VL - 12
SP - e12060
JO - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
IS - 1
M1 - e12060
ER -