TY - JOUR
T1 - Soluble adenylyl cyclase, the cell-autonomous member of the family
AU - Li, Hang Lam
AU - Go, Simei
AU - Chang, Jung-Chin
AU - Verhoeven, Arthur
AU - Elferink, Ronald Oude
N1 - Publisher Copyright: © 2023 The Authors
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Soluble adenylyl cyclase (sAC) is the evolutionarily most ancient of a set of 10 adenylyl cyclases (Adcys). While Adcy1 to Adcy9 are cAMP-producing enzymes that are activated by G-protein coupled receptors (GPCRs), Adcy10 (sAC) is an intracellular adenylyl cyclase. sAC plays a pivotal role in numerous cellular processes, ranging from basic physiological functions to complex signaling cascades. As a distinct member of the adenylyl cyclase family, sAC is not activated by GPCRs and stands apart due to its unique characteristics, regulation, and localization within cells. This minireview aims to honour Ulli Brandt, the outgoing Executive Editor of our journal, Biochimica Biophysica Acta (BBA), and longstanding Executive Editor of the BBA section Bioenergetics. We will therefore focus this review on bioenergetic aspects of sAC and, in addition, review some important recent general developments in the field of research on sAC.
AB - Soluble adenylyl cyclase (sAC) is the evolutionarily most ancient of a set of 10 adenylyl cyclases (Adcys). While Adcy1 to Adcy9 are cAMP-producing enzymes that are activated by G-protein coupled receptors (GPCRs), Adcy10 (sAC) is an intracellular adenylyl cyclase. sAC plays a pivotal role in numerous cellular processes, ranging from basic physiological functions to complex signaling cascades. As a distinct member of the adenylyl cyclase family, sAC is not activated by GPCRs and stands apart due to its unique characteristics, regulation, and localization within cells. This minireview aims to honour Ulli Brandt, the outgoing Executive Editor of our journal, Biochimica Biophysica Acta (BBA), and longstanding Executive Editor of the BBA section Bioenergetics. We will therefore focus this review on bioenergetic aspects of sAC and, in addition, review some important recent general developments in the field of research on sAC.
KW - Bicarbonate
KW - Cyclic AMP
KW - Intracellular pH
KW - Male infertility
KW - Metabolic regulation
KW - Soluble adenylyl cyclase
UR - http://www.scopus.com/inward/record.url?scp=85181395568&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.bbadis.2023.166936
DO - https://doi.org/10.1016/j.bbadis.2023.166936
M3 - Article
C2 - 37951509
SN - 0925-4439
VL - 1870
SP - 166936
JO - Biochimica et Biophysica Acta-Molecular Basis of Disease
JF - Biochimica et Biophysica Acta-Molecular Basis of Disease
IS - 2
M1 - 166936
ER -