Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection

M. H. Godfried; T. van der Poll; J. Jansen; J. A. Romijin; J. K. Schattenkerk; E. Endert; S. J. van Deventer; H. P. Sauerwein

doi:https://doi.org/10.1097/00002030-199301000-00005

Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection

M. H. Godfried, T. van der Poll, J. Jansen, J. A. Romijin, J. K. Schattenkerk, E. Endert, S. J. van Deventer, H. P. Sauerwein

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Abstract

To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection. We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated. Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts. Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection

Original language	English
Pages (from-to)	33-36
Journal	AIDS (London, England)
Volume	7
Issue number	1
DOIs	https://doi.org/10.1097/00002030-199301000-00005
Publication status	Published - 1993

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https://doi.org/10.1097/00002030-199301000-00005

Cite this

@article{c7d44a264f964f1e8c0ca3f5ffbf84d0,

title = "Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection",

abstract = "To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection. We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated. Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts. Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection",

author = "Godfried, {M. H.} and {van der Poll}, T. and J. Jansen and Romijin, {J. A.} and Schattenkerk, {J. K.} and E. Endert and {van Deventer}, {S. J.} and Sauerwein, {H. P.}",

year = "1993",

doi = "https://doi.org/10.1097/00002030-199301000-00005",

language = "English",

volume = "7",

pages = "33--36",

journal = "AIDS (London, England)",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "1",

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TY - JOUR

T1 - Soluble receptors for tumour necrosis factor: a putative marker of disease progression in HIV infection

AU - Godfried, M. H.

AU - van der Poll, T.

AU - Jansen, J.

AU - Romijin, J. A.

AU - Schattenkerk, J. K.

AU - Endert, E.

AU - van Deventer, S. J.

AU - Sauerwein, H. P.

PY - 1993

Y1 - 1993

N2 - To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection. We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated. Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts. Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection

AB - To assess the value of concentrations of soluble receptors for tumour necrosis factor (sTNFR) as markers for disease progression in HIV infection. We measured concentrations of sTNFR in the serum of 32 HIV-infected male patients in various stages of disease and in 12 healthy male control subjects. Correlations between the levels of sTNFR and CD4+ lymphocyte counts were calculated. Serum levels of sTNFR p55 and p75 were elevated in parallel with severity of clinical stage. sTNFR p55 levels were higher at later stages of HIV infection (Centers for Disease Control stage IV) with or without concurrent illness, whereas sTNFR p75 was already elevated in asymptomatic carriers, compared with controls. There was an inverse correlation between sTNFR concentrations and CD4+ lymphocyte counts. Our results suggest that sTNFR concentrations could be potential markers for disease progression in HIV infection

U2 - https://doi.org/10.1097/00002030-199301000-00005

DO - https://doi.org/10.1097/00002030-199301000-00005

M3 - Comment/Letter to the editor

C2 - 8382926

SN - 0269-9370

VL - 7

SP - 33

EP - 36

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 1

ER -