Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

M. Lijffijt; P.S. van Dam; J.L. Kenemans; H.P.F. Koppeschaar; W.R. de Vries; M.L. Drent; A. Wittenberg; C. Kemner

doi:https://doi.org/10.1016/j.neulet.2003.09.028

Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

M. Lijffijt, P.S. van Dam, J.L. Kenemans, H.P.F. Koppeschaar, W.R. de Vries, M.L. Drent, A. Wittenberg, C. Kemner

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	123-6
Number of pages	4
Journal	Neuroscience letters
Volume	353
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2003.09.028
Publication status	Published - 19 Dec 2003

Keywords

Adolescent
Adult
Attention/physiology
Brain/physiology
Evoked Potentials
Human Growth Hormone/deficiency
Humans
Insulin-Like Growth Factor I/deficiency
Male
Pattern Recognition, Visual/physiology
Photic Stimulation

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https://doi.org/10.1016/j.neulet.2003.09.028

Cite this

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title = "Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.",

abstract = "Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. {\textcopyright} 2003 Elsevier Ireland Ltd. All rights reserved.",

keywords = "Adolescent, Adult, Attention/physiology, Brain/physiology, Evoked Potentials, Human Growth Hormone/deficiency, Humans, Insulin-Like Growth Factor I/deficiency, Male, Pattern Recognition, Visual/physiology, Photic Stimulation",

author = "M. Lijffijt and {van Dam}, P.S. and J.L. Kenemans and H.P.F. Koppeschaar and {de Vries}, W.R. and M.L. Drent and A. Wittenberg and C. Kemner",

year = "2003",

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T1 - Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.

AU - Lijffijt, M.

AU - van Dam, P.S.

AU - Kenemans, J.L.

AU - Koppeschaar, H.P.F.

AU - de Vries, W.R.

AU - Drent, M.L.

AU - Wittenberg, A.

AU - Kemner, C.

PY - 2003/12/19

Y1 - 2003/12/19

N2 - Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

AB - Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. © 2003 Elsevier Ireland Ltd. All rights reserved.

KW - Adolescent

KW - Adult

KW - Attention/physiology

KW - Brain/physiology

KW - Evoked Potentials

KW - Human Growth Hormone/deficiency

KW - Humans

KW - Insulin-Like Growth Factor I/deficiency

KW - Male

KW - Pattern Recognition, Visual/physiology

KW - Photic Stimulation

U2 - https://doi.org/10.1016/j.neulet.2003.09.028

DO - https://doi.org/10.1016/j.neulet.2003.09.028

M3 - Article

C2 - 14664916

SN - 0304-3940

VL - 353

SP - 123

EP - 126

JO - Neuroscience letters

JF - Neuroscience letters

IS - 2

ER -