TY - JOUR
T1 - Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels-Alder Click Chemistry
AU - Brand, Christian
AU - Iacono, Pasquale
AU - Pérez-Medina, Carlos
AU - Mulder, Willem J. M.
AU - Kircher, Moritz F.
AU - Reiner, Thomas
PY - 2017
Y1 - 2017
N2 - Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels-Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized (89)Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, which were validated on a tetrazine-appended polydopamine-coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr-TCO-liposomal nanoparticles ((89)Zr-TCO-LNP) to be immobilized on the tetrazine surface to the control suspensions of non-TCO functionalized (89)Zr-liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non-targeted tissues by specific removal of long-circulating liposomal radiopharmaceuticals from the blood pool
AB - Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels-Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized (89)Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, which were validated on a tetrazine-appended polydopamine-coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr-TCO-liposomal nanoparticles ((89)Zr-TCO-LNP) to be immobilized on the tetrazine surface to the control suspensions of non-TCO functionalized (89)Zr-liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non-targeted tissues by specific removal of long-circulating liposomal radiopharmaceuticals from the blood pool
U2 - https://doi.org/10.1002/open.201700105
DO - https://doi.org/10.1002/open.201700105
M3 - Article
C2 - 29046855
SN - 2191-1363
VL - 6
SP - 615
EP - 619
JO - ChemistryOPEN
JF - ChemistryOPEN
IS - 5
ER -