Specific Chaperones for the Type VII Protein Secretion Pathway

M.H. Daleke, A.D. van der Woude, A.H.A. Parret, R. Ummels, A.M. Groot, D. Watson, S.R. Piersma, C.R. Jimenez, J. Luirink, W. Bitter, E.N.G. Houben

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68 Citations (Scopus)


Mycobacteria use the dedicated type VII protein secretion systems ESX-1 and ESX-5 to secrete virulence factors across their highly hydrophobic cell envelope. The substrates of these systems include the large mycobacterial PE and PPE protein families, which are named after their characteristic Pro-Glu and Pro-Pro-Glu motifs. Pathogenic mycobacteria secrete large numbers of PE/PPE proteins via the major export pathway, ESX-5. In addition, a few PE/PPE proteins have been shown to be exported by ESX-1. It is not known how ESX-1 and ESX-5 recognize their cognate PE/PPE substrates. In this work, we investigated the function of the cytosolic protein EspG
Original languageEnglish
Pages (from-to)31939-31947
JournalJournal of Biological Chemistry
Issue number38
Publication statusPublished - 2012

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