TY - JOUR
T1 - Spread of Mycobacterium tuberculosis in Southern Brazilian persons deprived of liberty
T2 - a molecular epidemiology study
AU - Busatto, Caroline
AU - Possuelo, Lia Gon?alves
AU - Bierhals, Dienefer
AU - de Oliveira, Carolina Larrosa
AU - de Souza, Mariana Quaresma
AU - Fanfa, Dandara
AU - Barreto, ?rika
AU - Schwarzbold, Pauline
AU - von Groll, Andrea
AU - Portugal, Isabel
AU - Perdig?o, Jo?o
AU - Croda, Julio
AU - Andrews, Jason R.
AU - da Silva, Pedro Almeida
AU - Ramis, Ivy Bastos
N1 - Funding Information: We would like to acknowledge the contributions of SUSEPE (Superintendence of Penitentiary Services), especially the 8th Regional Penitentiary Police Station/RS; LACEN/RS, especially Daniela Becker, and the Rio Grande do Sul State Health Department. Funding Information: This work was supported by the Coordenação de aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, and Programa Pesquisa para o SUS (PPSUS), Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS), 2017 Finance Code 17/2551—0001465–0. Publisher Copyright: © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/3
Y1 - 2023/3
N2 - To evaluate the genetic diversity and clustering rates of M. tuberculosis strains to better understand transmission among persons deprived of liberty (PDL) in Rio Grande do Sul (RS), southern Brazil. This is a cross-sectional study, including strains of M. tuberculosis isolated from PDL, stored at the Central Laboratory of RS, in the period from 2013 to 2018. The molecular characterization was performed using the MIRU-VNTR 15 loci method. A total of 598?M. tuberculosis strains were genotyped, and 37.5% were grouped into 53 clusters. Cluster sizes ranged from 2 to 34 strains. The largest cluster of the study had strains from 34 PDL, and 58.8% of the PDL of this cluster were in P01. Among the clusters formed, in 60.3%, there was at least one strain from P01. The most common strains in RS were LAM (53.2%) and Haarlem (31.1%). The LAM strain was the most likely to form clusters, and Haarlem was associated with anti-TB drug resistance. This was translational research, and the results can collaborate with the TB control programs, leading to improved strategies that allow the reduction of the TB burden in prisons.
AB - To evaluate the genetic diversity and clustering rates of M. tuberculosis strains to better understand transmission among persons deprived of liberty (PDL) in Rio Grande do Sul (RS), southern Brazil. This is a cross-sectional study, including strains of M. tuberculosis isolated from PDL, stored at the Central Laboratory of RS, in the period from 2013 to 2018. The molecular characterization was performed using the MIRU-VNTR 15 loci method. A total of 598?M. tuberculosis strains were genotyped, and 37.5% were grouped into 53 clusters. Cluster sizes ranged from 2 to 34 strains. The largest cluster of the study had strains from 34 PDL, and 58.8% of the PDL of this cluster were in P01. Among the clusters formed, in 60.3%, there was at least one strain from P01. The most common strains in RS were LAM (53.2%) and Haarlem (31.1%). The LAM strain was the most likely to form clusters, and Haarlem was associated with anti-TB drug resistance. This was translational research, and the results can collaborate with the TB control programs, leading to improved strategies that allow the reduction of the TB burden in prisons.
KW - Genotyping
KW - Phylogeny
KW - Prisons
KW - Transmission
KW - Tuberculosis
UR - http://www.scopus.com/inward/record.url?scp=85146827913&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s10096-023-04546-4
DO - https://doi.org/10.1007/s10096-023-04546-4
M3 - Article
C2 - 36701032
SN - 0934-9723
VL - 42
SP - 297
EP - 304
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 3
ER -