TY - JOUR
T1 - SSRIs vs. TCAs in the treatment of panic disorder
T2 - A meta-analysis
AU - Bakker, A.
AU - Van Balkom, A. J.L.M.
AU - Spinhoven, P.
PY - 2002/9
Y1 - 2002/9
N2 - Objective: To compare the short-term efficacy of selective serotonin reuptake inhibitors (SSRIs) vs. tricyclic antidepressants (TCAs) in the treatment of panic disorder (PD) a meta-analysis was conducted. Method: Included were 43 studies (34 randomized, nine open), pertaining to 53 treatment conditions, 2367 patients at pretest and 1804 at post-test. Outcome was measured with the proportion of patients becoming panic-free, and with pre/post Cohen's d effect sizes, calculated for four clinical variables: panic, agoraphobia, depression, and general anxiety. Results: There were no differences between SSRIs and TCAs on any of the effect sizes, indicating that both groups of antidepressants are equally effective in reducing panic symptoms, agoraphobic avoidance, depressive symptomatology and general anxiety. Also the percentage of patients free of panic attacks at post-test did not differ. The number of drop-outs, however, was significantly lower in the group of patients treated with SSRIs (18%) vs. TCAs (31%). Conclusion: SSRIs and TCAs are equal in efficacy in the treatment of panic disorder, but SSRIs are tolerated better.
AB - Objective: To compare the short-term efficacy of selective serotonin reuptake inhibitors (SSRIs) vs. tricyclic antidepressants (TCAs) in the treatment of panic disorder (PD) a meta-analysis was conducted. Method: Included were 43 studies (34 randomized, nine open), pertaining to 53 treatment conditions, 2367 patients at pretest and 1804 at post-test. Outcome was measured with the proportion of patients becoming panic-free, and with pre/post Cohen's d effect sizes, calculated for four clinical variables: panic, agoraphobia, depression, and general anxiety. Results: There were no differences between SSRIs and TCAs on any of the effect sizes, indicating that both groups of antidepressants are equally effective in reducing panic symptoms, agoraphobic avoidance, depressive symptomatology and general anxiety. Also the percentage of patients free of panic attacks at post-test did not differ. The number of drop-outs, however, was significantly lower in the group of patients treated with SSRIs (18%) vs. TCAs (31%). Conclusion: SSRIs and TCAs are equal in efficacy in the treatment of panic disorder, but SSRIs are tolerated better.
KW - Antidepressants
KW - Meta-analysis
KW - Panic disorder
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=0036738145&partnerID=8YFLogxK
U2 - https://doi.org/10.1034/j.1600-0447.2002.02255.x
DO - https://doi.org/10.1034/j.1600-0447.2002.02255.x
M3 - Review article
C2 - 12197851
SN - 0001-690X
VL - 106
SP - 163
EP - 167
JO - Acta psychiatrica Scandinavica
JF - Acta psychiatrica Scandinavica
IS - 3
ER -