Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy

Rieneke M. E. van Praag; Elisabeth C. M. van Weert; Rolf P. G. van Heeswijk; Xiao-Jian Zhou; Jean-Pierre Sommadossi; Suzanne Jurriaans; Joep M. A. Lange; Richard M. W. Hoetelmans; Jan M. Prins

doi:https://doi.org/10.1128/AAC.46.3.896-899.2002

Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy

Rieneke M. E. van Praag, Elisabeth C. M. van Weert, Rolf P. G. van Heeswijk, Xiao-Jian Zhou, Jean-Pierre Sommadossi, Suzanne Jurriaans, Joep M. A. Lange, Richard M. W. Hoetelmans, Jan M. Prins

Research output: Contribution to journal › Article › Academic › peer-review

34 Citations (Scopus)

Abstract

For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy

Original language	English
Pages (from-to)	896-899
Journal	Antimicrobial agents and chemotherapy
Volume	46
Issue number	3
DOIs	https://doi.org/10.1128/AAC.46.3.896-899.2002
Publication status	Published - 2002

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https://doi.org/10.1128/AAC.46.3.896-899.2002

Cite this

van Praag, R. M. E., van Weert, E. C. M., van Heeswijk, R. P. G., Zhou, X.-J., Sommadossi, J.-P., Jurriaans, S., Lange, J. M. A., Hoetelmans, R. M. W., & Prins, J. M. (2002). Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy. Antimicrobial agents and chemotherapy, 46(3), 896-899. https://doi.org/10.1128/AAC.46.3.896-899.2002

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title = "Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy",

abstract = "For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy",

author = "{van Praag}, {Rieneke M. E.} and {van Weert}, {Elisabeth C. M.} and {van Heeswijk}, {Rolf P. G.} and Xiao-Jian Zhou and Jean-Pierre Sommadossi and Suzanne Jurriaans and Lange, {Joep M. A.} and Hoetelmans, {Richard M. W.} and Prins, {Jan M.}",

year = "2002",

doi = "https://doi.org/10.1128/AAC.46.3.896-899.2002",

language = "English",

volume = "46",

pages = "896--899",

journal = "Antimicrobial agents and chemotherapy",

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publisher = "American Society for Microbiology",

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van Praag, RME, van Weert, ECM, van Heeswijk, RPG, Zhou, X-J, Sommadossi, J-P, Jurriaans, S, Lange, JMA, Hoetelmans, RMW & Prins, JM 2002, 'Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy', Antimicrobial agents and chemotherapy, vol. 46, no. 3, pp. 896-899. https://doi.org/10.1128/AAC.46.3.896-899.2002

Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy. / van Praag, Rieneke M. E.; van Weert, Elisabeth C. M.; van Heeswijk, Rolf P. G. et al.
In: Antimicrobial agents and chemotherapy, Vol. 46, No. 3, 2002, p. 896-899.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Stable concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid during 2 years of therapy

AU - van Praag, Rieneke M. E.

AU - van Weert, Elisabeth C. M.

AU - van Heeswijk, Rolf P. G.

AU - Zhou, Xiao-Jian

AU - Sommadossi, Jean-Pierre

AU - Jurriaans, Suzanne

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AU - Hoetelmans, Richard M. W.

AU - Prins, Jan M.

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AB - For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy

U2 - https://doi.org/10.1128/AAC.46.3.896-899.2002

DO - https://doi.org/10.1128/AAC.46.3.896-899.2002

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SN - 0066-4804

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