TY - JOUR
T1 - Standardized nailfold capillaroscopy in children with rheumatic diseases
T2 - a worldwide study
AU - Melsens, Karin
AU - Cutolo, Maurizio
AU - Schonenberg-Meinema, Dieneke
AU - Foeldvari, Ivan
AU - Leone, Maria C.
AU - Mostmans, Yora
AU - Badot, Valérie
AU - Cimaz, Rolando
AU - Dehoorne, Joke
AU - Deschepper, Ellen
AU - Frech, Tracy
AU - Hernandez-Zapata, Johanna
AU - Ingegnoli, Francesca
AU - Khan, Archana
AU - Krasowska, Dorota
AU - Lehmann, Hartwig
AU - Makol, Ashima
AU - Mesa-Navas, Miguel A.
AU - Michalska-Jakubus, Malgorzata
AU - Müller-Ladner, Ulf
AU - Nuño-Nuño, Laura
AU - Overbury, Rebecca
AU - Pizzorni, Carmen
AU - Radic, Mislav
AU - Ramadoss, Divya
AU - Ravelli, Angelo
AU - Rosina, Silvia
AU - Udaondo, Clara
AU - van den Berg, Merlijn J.
AU - Herrick, Ariane L.
AU - Sulli, Alberto
AU - EULAR Study Group on Microcirculation in Rheumatic Diseases
AU - Smith, Vanessa
N1 - Funding Information: V.S. is a senior clinical investigator of the Research Foundation-Flanders (Belgium) (FWO) (1.8.029.20N). The FWO was not involved in the study design; collection, analysis and interpretation of data; writing of the report or the decision to submit the manuscript for publication. She is supported by an unrestricted educational chair on systemic sclerosis from Janssen-Cilag NV. Janssen-Cilag NV was not involved in the study design; collection, analysis and interpretation of data; writing of the report or the decision to submit the manuscript for publication. M.C.L. was a research fellow who received a EULAR scientific training bursary during the data acquisition period of the study. Publisher Copyright: © 2023 Oxford University Press. All rights reserved.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - Objectives: To standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs). Material and methods: In consecutive jRMD children and matched HCs from 13 centres worldwide, 16 NVC images per patient were acquired locally and read centrally per international consensus standard evaluation of the EULAR Study Group on Microcirculation in Rheumatic Diseases. A total of 95 patients with JIA, 22 with JDM, 20 with childhood-onset SLE (cSLE), 13 with juvenile SSc (jSSc), 21 with localized scleroderma (lSc), 18 with MCTD and 20 with primary RP (PRP) were included. NVC differences between juvenile subgroups and HCs were calculated through multivariable regression analysis. Results: A total of 6474 images were assessed from 413 subjects (mean age 12.1 years, 70.9% female). The quantitative NVC characteristics were significantly lower or higher in the following subgroups compared with HCs: for density: lower in jSSc, JDM, MCTD, cSLE and lSc; for dilations: higher in jSSc, MCTD and JDM; for abnormal shapes: higher in JDM and MCTD; for haemorrhages: higher in jSSc, MCTD, JDM and cSLE. The qualitative NVC assessment of JIA, lSc and PRP did not differ from HCs, whereas the cSLE and jSSc, MCTD, JDM and cSLE subgroups showed more non-specific and scleroderma patterns, respectively. Conclusions: This analysis resulted from a pioneering registry of NVC in jRMD. The NVC assessment in jRMD differed significantly from HCs. Future prospective follow-up will further elucidate the role of NVC in jRMD. VC The Author(s) 2022.
AB - Objectives: To standardly assess and describe nailfold videocapillaroscopy (NVC) assessment in children and adolescents with juvenile rheumatic and musculoskeletal diseases (jRMD) vs healthy controls (HCs). Material and methods: In consecutive jRMD children and matched HCs from 13 centres worldwide, 16 NVC images per patient were acquired locally and read centrally per international consensus standard evaluation of the EULAR Study Group on Microcirculation in Rheumatic Diseases. A total of 95 patients with JIA, 22 with JDM, 20 with childhood-onset SLE (cSLE), 13 with juvenile SSc (jSSc), 21 with localized scleroderma (lSc), 18 with MCTD and 20 with primary RP (PRP) were included. NVC differences between juvenile subgroups and HCs were calculated through multivariable regression analysis. Results: A total of 6474 images were assessed from 413 subjects (mean age 12.1 years, 70.9% female). The quantitative NVC characteristics were significantly lower or higher in the following subgroups compared with HCs: for density: lower in jSSc, JDM, MCTD, cSLE and lSc; for dilations: higher in jSSc, MCTD and JDM; for abnormal shapes: higher in JDM and MCTD; for haemorrhages: higher in jSSc, MCTD, JDM and cSLE. The qualitative NVC assessment of JIA, lSc and PRP did not differ from HCs, whereas the cSLE and jSSc, MCTD, JDM and cSLE subgroups showed more non-specific and scleroderma patterns, respectively. Conclusions: This analysis resulted from a pioneering registry of NVC in jRMD. The NVC assessment in jRMD differed significantly from HCs. Future prospective follow-up will further elucidate the role of NVC in jRMD. VC The Author(s) 2022.
KW - children
KW - juvenile rheumatic and musculoskeletal diseases
KW - microcirculation
KW - nailfold capillaroscopy
KW - scleroderma pattern
UR - http://www.scopus.com/inward/record.url?scp=85151499928&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/rheumatology/keac487
DO - https://doi.org/10.1093/rheumatology/keac487
M3 - Article
C2 - 36005889
SN - 1462-0324
VL - 62
SP - 1605
EP - 1615
JO - Rheumatology (Oxford, England)
JF - Rheumatology (Oxford, England)
IS - 4
ER -