Standing Up Slowly Antagonises Initial Blood Pressure Decrease in Older Adults with Orthostatic Hypotension

Eline S de Bruïne, Esmee M Reijnierse, Marijke C Trappenburg, Jantsje H Pasma, Oscar J de Vries, Carel G M Meskers, Andrea B Maier

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


BACKGROUND: Orthostatic hypotension (OH) is common in older adults and associated with increased morbidity and mortality, loss of independence and high health-care costs. Standing up slowly is a recommended non-pharmacological intervention. However, the effectiveness of this advice has not been well studied.

OBJECTIVES: The aim of this study was to investigate whether standing up slowly antagonises posture-related blood pressure (BP) decrease in a clinically relevant population of geriatric outpatients.

METHODS: In this cross-sectional study, 24 community-dwelling older adults referred to a geriatric outpatient clinic and diagnosed with OH were included. BP was measured continuously during 3 consecutive transitions from supine to standing position during normal, slow and fast transition.

RESULTS: The relative BP decrease at 0-15 s after slow transition was significantly lower than after normal transition (p = 0.003 for both systolic BP and diastolic BP) and fast transition (p = 0.045 for systolic BP; diastolic BP: non-significant). The relative diastolic BP decrease at 60-180 s after normal transition was significantly lower than after fast transition (p = 0.029).

CONCLUSION: Standing up slowly antagonises BP decrease predominantly during the first 15 s of standing up in a clinically relevant population of geriatric outpatients diagnosed with OH. Results support the non-pharmacological intervention in clinical practice to counteract OH.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
Issue number2
Early online date19 Oct 2016
Publication statusPublished - 1 Feb 2017


  • Accidental Falls/prevention & control
  • Aged
  • Aged, 80 and over
  • Aging/physiology
  • Blood Pressure Determination/methods
  • Blood Pressure/physiology
  • Blood pressure
  • Continuously measured blood pressure
  • Cross-Sectional Studies
  • Female
  • Humans
  • Hypotension, Orthostatic/physiopathology
  • Male
  • Older adults
  • Orthostatic hypotension
  • Posture/physiology
  • Stance
  • Standing up slowly
  • Time Factors

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