Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes

Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen, Folkert Kuipers, James M. Ntambi

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Previous studies showed that mice deficient in Scd1 had a reduced level of liver triglyceride and an improvement in insulin sensitivity. We studied Scd1(-/-) mice on a very low-fat, high-carbohydrate lipogenic diet. The animals were almost entirely devoid of high-density lipoprotein (HDL). Nonetheless, they were hypercholesterolemic and had cholestasis. These changes were reversible with oil containing both mono- and polyunsaturated fat, but not entirely reversible with just triolein, suggesting that Scd1 deficiency increased the requirement for polyunsaturated fat. We also found that the Scd1(-/-) mice on a normal chow diet had dramatically improved insulin sensitivity. However, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice
Original languageEnglish
Pages (from-to)S35-S38
JournalNutrition reviews
Issue number6 Part 2
Publication statusPublished - 2007

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