Stem cell dynamics in homeostasis and cancer of the intestine

Louis Vermeulen; Hugo J. Snippert

doi:https://doi.org/10.1038/nrc3744

Stem cell dynamics in homeostasis and cancer of the intestine

Louis Vermeulen, Hugo J. Snippert

Center of Experimental and Molecular Medicine (AMC)

Research output: Contribution to journal › Review article › Academic › peer-review

189 Citations (Scopus)

Abstract

Intestinal stem cells (ISCs) and colorectal cancer (CRC) biology are tightly linked in many aspects. It is generally thought that ISCs are the cells of origin for a large proportion of CRCs and crucial ISC-associated signalling pathways are often affected in CRCs. Moreover, CRCs are thought to retain a cellular hierarchy that is reminiscent of the intestinal epithelium. Recent studies offer quantitative insights into the dynamics of ISC behaviour that govern homeostasis and thereby provide the necessary baseline parameters to begin to apply these analyses during the various stages of tumour development

Original language	English
Pages (from-to)	468-480
Journal	Nature reviews. Cancer
Volume	14
Issue number	7
DOIs	https://doi.org/10.1038/nrc3744
Publication status	Published - 2014

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https://doi.org/10.1038/nrc3744

Cite this

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