Stem cell dynamics in homeostasis and cancer of the intestine

Louis Vermeulen, Hugo J. Snippert

Research output: Contribution to journalReview articleAcademicpeer-review

189 Citations (Scopus)

Abstract

Intestinal stem cells (ISCs) and colorectal cancer (CRC) biology are tightly linked in many aspects. It is generally thought that ISCs are the cells of origin for a large proportion of CRCs and crucial ISC-associated signalling pathways are often affected in CRCs. Moreover, CRCs are thought to retain a cellular hierarchy that is reminiscent of the intestinal epithelium. Recent studies offer quantitative insights into the dynamics of ISC behaviour that govern homeostasis and thereby provide the necessary baseline parameters to begin to apply these analyses during the various stages of tumour development
Original languageEnglish
Pages (from-to)468-480
JournalNature reviews. Cancer
Volume14
Issue number7
DOIs
Publication statusPublished - 2014

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