TY - JOUR
T1 - Structure, function, and relevance of thyroid peroxidase in inherited diseases of the thyroid
AU - De Vijlder, Jan J.M.
AU - Bikker, Hennie
AU - Ris-Stalpers, Carrie
AU - Vulsma, Thomas
PY - 1997
Y1 - 1997
N2 - Recent advances have been made in the research on structure and function of thyroid peroxidase in the field of the reaction mechanism with respect to the involvement of compound I in iodination and thyroid hormonogenesis. New information has become available concerning the mechanism of thyroid peroxidase autoantibody formation and immunodominant domains on the thyroid peroxidase molecule. In certain types of hereditary congenital hypothyroidism, called total iodide organification defects, thyroid peroxidase is impaired owing to mutations in the thyroid peroxidase gene. Detailed investigations on the proteins expressed in vitro have been described.
AB - Recent advances have been made in the research on structure and function of thyroid peroxidase in the field of the reaction mechanism with respect to the involvement of compound I in iodination and thyroid hormonogenesis. New information has become available concerning the mechanism of thyroid peroxidase autoantibody formation and immunodominant domains on the thyroid peroxidase molecule. In certain types of hereditary congenital hypothyroidism, called total iodide organification defects, thyroid peroxidase is impaired owing to mutations in the thyroid peroxidase gene. Detailed investigations on the proteins expressed in vitro have been described.
UR - http://www.scopus.com/inward/record.url?scp=9844246958&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/00060793-199710000-00003
DO - https://doi.org/10.1097/00060793-199710000-00003
M3 - Article
SN - 1068-3097
VL - 4
SP - 328
EP - 332
JO - Current opinion in endocrinology and diabetes
JF - Current opinion in endocrinology and diabetes
IS - 5
ER -