TY - JOUR
T1 - Structure-function mapping using a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography volume scans
AU - Celebi, Ali Riza Cenk
AU - Park, Elli A.
AU - Vercellin, Alice Chandra Verticchio
AU - Tsikata, Edem
AU - Lee, Ramon
AU - Shieh, Eric
AU - Antar, Hussein
AU - Freeman, Madeline
AU - Zhang, Jing
AU - Que, Christian
AU - Simavli, Huseyin
AU - McClurkin, Michael
AU - Guo, Rong
AU - Elze, Tobias
AU - De Boer, Johannes F.
AU - Chen, Teresa C.
N1 - Funding Information: T.C.C. received funding from the National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016. Publisher Copyright: © 2021 The Authors. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5
Y1 - 2021/5
N2 - Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.
AB - Purpose: To assess the structure-function relationship in glaucoma using Humphrey visual field (HVF) perimetry and a three-dimensional neuroretinal rim parameter derived from spectral domain optical coherence tomography (SD-OCT) volume scans.Methods: Structure-function correlation was analyzed globally and regionally (four quadrants and four sectors). Structural data included peripapillary retinal nerve fiber layer (RNFL) thickness and minimum distance band (MDB) neuroretinal rim thick-ness, defined as the shortest distance between the inner cup surface and the outer retinal pigment epithelium/Bruch’s membrane complex. Logarithmic regression analyses were performed and Pearson correlation coefficients determined to assess relationship strength.Results: The study consisted of 102 open-angle glaucoma patients and 58 healthy subjects. The Pearson correlation coefficient for global MDB thickness (R = 0.585) was higher than for global RNFL thickness (R = 0.492), but the difference was not statisti-cally significant (P = 0.18). The correlation coefficients for regional MDB thicknesses and corresponding HVF sensitivities were higher than those for regional RNFL thicknesses and HVF in six out of eight regions (P = 0.08 to 0.47). In the remaining two out of eight regions, the correlation coefficients were higher for RNFL thickness than for MDB thickness (P = 0.15 to 0.20).Conclusions: Three-dimensional MDB neuroretinal rim thickness relates to visual function as strongly as the most commonly used SD-OCT parameter for glaucoma, two-dimensional peripapillary RNFL thickness.
KW - Glaucoma
KW - Minimum distance band
KW - Retinal nerve fiber layer
KW - Spectral domain optical coherence tomography
KW - Structure-function relationship
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U2 - https://doi.org/10.1167/TVST.10.6.28
DO - https://doi.org/10.1167/TVST.10.6.28
M3 - Article
SN - 2164-2591
VL - 10
SP - 1
EP - 13
JO - Translational Vision Science and Technology
JF - Translational Vision Science and Technology
IS - 6
M1 - 28
ER -