TY - JOUR
T1 - Studies on long-lasting consequences of prenatal exposure to anticonvulsant drugs.
AU - Dessens, A. B.
AU - Boer, K.
AU - Koppe, J. G.
AU - van de Poll, N. E.
AU - Cohen-Kettenis, P. T.
PY - 1994/11/1
Y1 - 1994/11/1
N2 - Based on neonatal examination at birth, it has been estimated that epileptic women have a 2-3 times greater risk of giving birth to an infant with congenital anomalies. But anticonvulsant drugs may also have more subtle influences on the developing foetus which are not visible at birth but only emerge later in life. Evidence for these functional teratogenic influences has been provided by animal research and follow-up studies in young children. This article discusses these findings in human and animal studies. In addition, the outline of a study carried out at the Department of Obstetrics and Neonatology, Academic Medical Centre, Amsterdam, is described. In this study cognitive functioning, fertility and gender role behaviour of young adults, who had been prenatally exposed to barbiturates and/or hydantoins was examined.
AB - Based on neonatal examination at birth, it has been estimated that epileptic women have a 2-3 times greater risk of giving birth to an infant with congenital anomalies. But anticonvulsant drugs may also have more subtle influences on the developing foetus which are not visible at birth but only emerge later in life. Evidence for these functional teratogenic influences has been provided by animal research and follow-up studies in young children. This article discusses these findings in human and animal studies. In addition, the outline of a study carried out at the Department of Obstetrics and Neonatology, Academic Medical Centre, Amsterdam, is described. In this study cognitive functioning, fertility and gender role behaviour of young adults, who had been prenatally exposed to barbiturates and/or hydantoins was examined.
KW - Anticonvulsant drugs
KW - barbiturates
KW - cognitive functioning
KW - delayed effects
KW - functional teratology
KW - gender
KW - hydantoins
KW - prenatal exposure
KW - reproductivity
UR - http://www.scopus.com/inward/record.url?scp=0028542316&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/record.url?scp=0027997025&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/j.1651-2227.1994.tb13385.x
DO - https://doi.org/10.1111/j.1651-2227.1994.tb13385.x
M3 - Review article
C2 - 7531043
SN - 0803-5326
VL - 404
SP - 54
EP - 64
JO - Acta paediatrica (Oslo, Norway : 1992). Supplement
JF - Acta paediatrica (Oslo, Norway : 1992). Supplement
IS - Suppl. 404
ER -