SUMOylation and PPARgamma: wrestling with inflammatory signaling

Noam Zelcer; Peter Tontonoz

doi:https://doi.org/10.1016/j.cmet.2005.10.004

SUMOylation and PPARgamma: wrestling with inflammatory signaling

Noam Zelcer, Peter Tontonoz

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Research output: Contribution to journal › Editorial › Academic › peer-review

20 Citations (Scopus)

Abstract

The molecular mechanisms whereby PPARgamma inhibits inflammatory gene expression in macrophages are poorly understood. In a recent Nature paper, provide a new model for trans-repression in which ligand-dependent SUMOylation of PPARgamma results in its recruitment to the promoters of inflammatory genes where it inhibits transcription by preventing clearance of corepressor complexes

Original language	English
Pages (from-to)	273-275
Journal	Cell metabolism
Volume	2
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2005.10.004
Publication status	Published - 2005

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https://doi.org/10.1016/j.cmet.2005.10.004

Cite this

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title = "SUMOylation and PPARgamma: wrestling with inflammatory signaling",

abstract = "The molecular mechanisms whereby PPARgamma inhibits inflammatory gene expression in macrophages are poorly understood. In a recent Nature paper, provide a new model for trans-repression in which ligand-dependent SUMOylation of PPARgamma results in its recruitment to the promoters of inflammatory genes where it inhibits transcription by preventing clearance of corepressor complexes",

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