TY - JOUR
T1 - Superior Sensibility after Full Breast Reconstruction with Autologous Fat Transfer
AU - Wederfoort, Jamilla L. M.
AU - Schop, Sander
AU - van der Broeck, Lotte C. A.
AU - Hommes, Juliette E.
AU - van Kuijk, Sander M. J.
AU - Timmermans, Floyd
AU - Smit, Jan Maerten
AU - Heuts, Esther M.
AU - de Wit, Thijs
AU - van der Hulst, René R. W. J.
AU - Piatkowski, Andrzej A.
N1 - Publisher Copyright: © 2023 The Authors.
PY - 2024/2/1
Y1 - 2024/2/1
N2 - Background: With developments in screening and treatment, survival rates of breast cancer patients are increasing, and so is the number of women opting for breast reconstruction to improve their quality of life. One factor that could play an important role in improving the quality of life is breast sensibility. Therefore, the aim of this study was to explore breast sensibility in participants of the Breast Reconstruction with External Preexpansion and Autologous Fat Transfer versus Standard Therapy trial: an ongoing randomized controlled trial comparing breast reconstruction with autologous fat transfer (AFT) versus implant-based reconstruction (IBR). Methods: This study was conducted on participants of the Breast Reconstruction with External Preexpansion and Autologous Fat Transfer versus Standard Therapy trial who were at least 12 months after final surgery. Semmes-Weinstein monofilaments were used to measure skin sensibility in breast cancer patients who underwent breast reconstruction with either AFT or IBR following their mastectomy. Results: A total of 46 patients were included in this study, resulting in 62 breast reconstructions (28 AFT breasts and 34 IBR breasts). Significantly higher mean monofilament values were found for skin sensibility after AFT (-0.7; P < 0.001), clinically correlating to “diminished protective function,” as opposed to the IBR group, with clinical values indicating “loss of protective function.” Conclusions: In this study, the authors found that breast cancer patients who underwent a mastectomy had a significantly better sensibility of the breast following AFT for total breast reconstruction as compared with IBR. Larger studies that include null measurements are required to further explore these noteworthy results of AFT. (Plast. Reconstr. Surg. 153: 316, 2024.) CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
AB - Background: With developments in screening and treatment, survival rates of breast cancer patients are increasing, and so is the number of women opting for breast reconstruction to improve their quality of life. One factor that could play an important role in improving the quality of life is breast sensibility. Therefore, the aim of this study was to explore breast sensibility in participants of the Breast Reconstruction with External Preexpansion and Autologous Fat Transfer versus Standard Therapy trial: an ongoing randomized controlled trial comparing breast reconstruction with autologous fat transfer (AFT) versus implant-based reconstruction (IBR). Methods: This study was conducted on participants of the Breast Reconstruction with External Preexpansion and Autologous Fat Transfer versus Standard Therapy trial who were at least 12 months after final surgery. Semmes-Weinstein monofilaments were used to measure skin sensibility in breast cancer patients who underwent breast reconstruction with either AFT or IBR following their mastectomy. Results: A total of 46 patients were included in this study, resulting in 62 breast reconstructions (28 AFT breasts and 34 IBR breasts). Significantly higher mean monofilament values were found for skin sensibility after AFT (-0.7; P < 0.001), clinically correlating to “diminished protective function,” as opposed to the IBR group, with clinical values indicating “loss of protective function.” Conclusions: In this study, the authors found that breast cancer patients who underwent a mastectomy had a significantly better sensibility of the breast following AFT for total breast reconstruction as compared with IBR. Larger studies that include null measurements are required to further explore these noteworthy results of AFT. (Plast. Reconstr. Surg. 153: 316, 2024.) CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, II.
UR - http://www.scopus.com/inward/record.url?scp=85183450619&partnerID=8YFLogxK
U2 - 10.1097/PRS.0000000000010619
DO - 10.1097/PRS.0000000000010619
M3 - Article
C2 - 37114918
SN - 0032-1052
VL - 153
SP - 316
EP - 323
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
IS - 2
ER -