Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

Taco J De Vries, Wendy de Vries, Mieke C W Janssen, Anton N M Schoffelmeer

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Scopus)


The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

Original languageEnglish
Pages (from-to)164-8
Number of pages5
JournalBehavioural Brain Research
Issue number1
Early online date3 Jun 2005
Publication statusPublished - 3 Jun 2005


  • Animals
  • Behavior, Animal
  • Cannabinoid Receptor Antagonists
  • Comparative Study
  • Conditioning, Operant
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Extinction, Psychological
  • Inhibition (Psychology)
  • Journal Article
  • Male
  • Nicotine
  • Nicotinic Agonists
  • Piperidines
  • Pyrazoles
  • Rats
  • Rats, Wistar
  • Sucrose
  • Sweetening Agents

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