Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

Taco J De Vries; Wendy de Vries; Mieke C W Janssen; Anton N M Schoffelmeer

doi:https://doi.org/10.1016/j.bbr.2005.02.021

Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A

Taco J De Vries, Wendy de Vries, Mieke C W Janssen, Anton N M Schoffelmeer

Research output: Contribution to journal › Article › Academic › peer-review

90 Citations (Scopus)

Abstract

The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.

Original language	English
Pages (from-to)	164-8
Number of pages	5
Journal	Behavioural Brain Research
Volume	161
Issue number	1
Early online date	3 Jun 2005
DOIs	https://doi.org/10.1016/j.bbr.2005.02.021
Publication status	Published - 3 Jun 2005

Keywords

Animals
Behavior, Animal
Cannabinoid Receptor Antagonists
Comparative Study
Conditioning, Operant
Dose-Response Relationship, Drug
Drug Interactions
Extinction, Psychological
Inhibition (Psychology)
Journal Article
Male
Nicotine
Nicotinic Agonists
Piperidines
Pyrazoles
Rats
Rats, Wistar
Sucrose
Sweetening Agents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1016/j.bbr.2005.02.021

Cite this

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title = "Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A",

abstract = "The present study shows that the selective cannabinoid CB1 receptor antagonist SR141716A attenuated responding for both nicotine- and sucrose-associated stimuli in a long-term extinction-reinstatement model. The results suggest that endocannabinoids play a general role in modulating cue reactivity or conditioned reinforcement following prolonged abstinence of both drug and natural reinforcers. In line with previous preclinical and recent clinical observations, our results provide a strong rationale for the use of CB1 antagonists in the treatment of addictive behaviors.",

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author = "{De Vries}, {Taco J} and {de Vries}, Wendy and Janssen, {Mieke C W} and Schoffelmeer, {Anton N M}",

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AU - de Vries, Wendy

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AU - Schoffelmeer, Anton N M

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KW - Inhibition (Psychology)

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