Surgery for psychiatric disorders.

Judy Luigjes; Bart P. de Kwaasteniet; Pelle P. de Koning; Marloes S. Oudijn; Pepijn van den Munckhof; P. Richard Schuurman; Damiaan Denys

doi:https://doi.org/10.1016/j.wneu.2012.03.009

Surgery for psychiatric disorders.

Judy Luigjes, Bart P. de Kwaasteniet, Pelle P. de Koning, Marloes S. Oudijn, Pepijn van den Munckhof, P. Richard Schuurman, Damiaan Denys

Research output: Contribution to journal › Review article › Academic › peer-review

37 Citations (Scopus)

Abstract

Surgery in psychiatric disorders has a long history and has regained momentum in the past few decades with deep brain stimulation (DBS). DBS is an adjustable and reversible neurosurgical intervention using implanted electrodes to deliver controlled electrical pulses to targeted areas of the brain. It holds great promise for therapy-refractory obsessive-compulsive disorder. Several double-blind controlled and open trials have been conducted and the response rate is estimated around 54%. Open trials have shown encouraging results with DBS for therapy-refractory depression and case reports have shown potential effects of DBS on addiction. Another promising indication is Tourette syndrome, where potential efficacy of DBS is shown by several case series and a few controlled trials. Further research should focus on optimizing DBS with respect to target location and increasing the number of controlled double-blinded trials. In addition, new indications for DBS and new target options should be explored in preclinical research. Copyright © 2013 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	S31.e17-S31.e28
Journal	World Neurosurgery
Volume	80
Issue number	3-4
DOIs	https://doi.org/10.1016/j.wneu.2012.03.009
Publication status	Published - 2013

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title = "Surgery for psychiatric disorders.",

abstract = "Surgery in psychiatric disorders has a long history and has regained momentum in the past few decades with deep brain stimulation (DBS). DBS is an adjustable and reversible neurosurgical intervention using implanted electrodes to deliver controlled electrical pulses to targeted areas of the brain. It holds great promise for therapy-refractory obsessive-compulsive disorder. Several double-blind controlled and open trials have been conducted and the response rate is estimated around 54%. Open trials have shown encouraging results with DBS for therapy-refractory depression and case reports have shown potential effects of DBS on addiction. Another promising indication is Tourette syndrome, where potential efficacy of DBS is shown by several case series and a few controlled trials. Further research should focus on optimizing DBS with respect to target location and increasing the number of controlled double-blinded trials. In addition, new indications for DBS and new target options should be explored in preclinical research. Copyright {\textcopyright} 2013 Elsevier Inc. All rights reserved.",

author = "Judy Luigjes and {de Kwaasteniet}, {Bart P.} and {de Koning}, {Pelle P.} and Oudijn, {Marloes S.} and {van den Munckhof}, Pepijn and Schuurman, {P. Richard} and Damiaan Denys",

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T1 - Surgery for psychiatric disorders.

AU - Luigjes, Judy

AU - de Kwaasteniet, Bart P.

AU - de Koning, Pelle P.

AU - Oudijn, Marloes S.

AU - van den Munckhof, Pepijn

AU - Schuurman, P. Richard

AU - Denys, Damiaan

PY - 2013

Y1 - 2013

N2 - Surgery in psychiatric disorders has a long history and has regained momentum in the past few decades with deep brain stimulation (DBS). DBS is an adjustable and reversible neurosurgical intervention using implanted electrodes to deliver controlled electrical pulses to targeted areas of the brain. It holds great promise for therapy-refractory obsessive-compulsive disorder. Several double-blind controlled and open trials have been conducted and the response rate is estimated around 54%. Open trials have shown encouraging results with DBS for therapy-refractory depression and case reports have shown potential effects of DBS on addiction. Another promising indication is Tourette syndrome, where potential efficacy of DBS is shown by several case series and a few controlled trials. Further research should focus on optimizing DBS with respect to target location and increasing the number of controlled double-blinded trials. In addition, new indications for DBS and new target options should be explored in preclinical research. Copyright © 2013 Elsevier Inc. All rights reserved.

AB - Surgery in psychiatric disorders has a long history and has regained momentum in the past few decades with deep brain stimulation (DBS). DBS is an adjustable and reversible neurosurgical intervention using implanted electrodes to deliver controlled electrical pulses to targeted areas of the brain. It holds great promise for therapy-refractory obsessive-compulsive disorder. Several double-blind controlled and open trials have been conducted and the response rate is estimated around 54%. Open trials have shown encouraging results with DBS for therapy-refractory depression and case reports have shown potential effects of DBS on addiction. Another promising indication is Tourette syndrome, where potential efficacy of DBS is shown by several case series and a few controlled trials. Further research should focus on optimizing DBS with respect to target location and increasing the number of controlled double-blinded trials. In addition, new indications for DBS and new target options should be explored in preclinical research. Copyright © 2013 Elsevier Inc. All rights reserved.

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U2 - https://doi.org/10.1016/j.wneu.2012.03.009

DO - https://doi.org/10.1016/j.wneu.2012.03.009

M3 - Review article

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VL - 80

SP - S31.e17-S31.e28

JO - World Neurosurgery

JF - World Neurosurgery

IS - 3-4

ER -

Surgery for psychiatric disorders.

Abstract

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