Sweet and sour--oxidative and carbonyl stress in neurological disorders

Robert A Harris, Sandra Amor

Research output: Contribution to journalReview articleAcademicpeer-review

29 Citations (Scopus)


The nervous system is a unique network of different cell types and comprises a variety of proteins, lipids, and carbohydrates that have an important interplay with all major organs in the body. Homeostatic regulation of nervous tissue turnover must be carefully controlled, taking into account interactions of the nervous, endocrine, and immune systems. Clinical conditions affecting the nervous system range from mild cognitive perturbations such as headache, to life-threatening acute courses such as meningitis and glioblastoma, and to chronic neurodegenerative diseases such as multiple sclerosis. One unifying feature in normal developmental or homeostatic functions and clinical dysfunctions within the nervous system is redox regulation, with an imbalance in oxidative/carbonyl stress versus antioxidants being characteristic of pathological conditions. In this review we consider the state of current knowledge regarding structural, genetic, proteomic, histopathological, clinical, and therapeutic perspectives of oxidative and carbonyl stress within the nervous system.

Original languageEnglish
Pages (from-to)82-107
Number of pages26
JournalCNS and Neurological Disorders. Drug Targets
Issue number1
Publication statusPublished - Feb 2011


  • Antioxidants
  • Glycation End Products, Advanced
  • Humans
  • Journal Article
  • Lipid Peroxidation
  • Molecular Targeted Therapy
  • Nervous System Diseases
  • Neurodegenerative Diseases
  • Oxidation-Reduction
  • Oxidative Stress
  • Reactive Oxygen Species
  • Receptor for Advanced Glycation End Products
  • Receptors, Immunologic
  • Research Support, Non-U.S. Gov't
  • Review

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